磁性纳米复合材料负载铜，钯催化的CuAAC和Suzuki反应研究

发布时间：2018-06-23 09:05

本文选题：羧甲基纤维素 + 磁性纳米载体　；参考：《暨南大学》2017年硕士论文

【摘要】：CuAAC反应提供了一种在温和的条件下高选择性地合成1,2,3-三唑的方法。1,2,3-三唑是一种化学稳定性较好的五元含氮杂环化合物,在生物化学、药物科学、材料科学、以及有机合成等研究领域均有应用。Suzuki偶联反应是一种有效的构建C-C键的途径,其合成产物广泛应用于药物和先进材料。近些年来,改性磁性纳米粒子表面嵌入载体增强催化活性得到了极大重视。磁性纳米催化剂的最主要优点是具有高的催化活性,同时在磁铁的作用下能有效在反应体系中将催化剂分离出来。本论文具体研究细节如下:1.利用制备的Carboxymethylcellulose/Fe_3O_4磁性纳米复合材料与二价铜离子交换制备CuII-CMC-Fe_3O_4催化剂,并将其应用于催化CuAAC反应研究。结果表明,该催化剂能在较温和条件下高效催化卤化苄、叠氮化钠与末端炔烃反应,且催化剂与产物通过磁铁作用易于分离回收循环利用。2.将已经制备的Carboxymethylcellulose/Fe_3O_4磁性纳米复合材料与氯化钯通过离子交换还原得到Pd0@CMC/Fe_3O_4催化剂用于催化卤代芳烃与芳基硼酸参与的Suzuki交叉偶联反应。结果表明,反应只需较短时间就可高效完成,且产率较高、反应条件温和、催化剂稳定性较好且在永久磁铁的作用下易于回收重复使用。
[Abstract]:CuAAC reaction provides a highly selective method for the synthesis of 1t2O3- triazole under mild conditions. It is a chemical stable heterocyclic compound containing nitrogen in biochemistry, pharmaceutical science, and material science. Suzuki coupling reaction is an effective way to construct C-C bond, and its synthetic products are widely used in drugs and advanced materials. In recent years, much attention has been paid to the enhancement of catalytic activity of the surface embedded support of modified magnetic nanoparticles. The main advantage of magnetic nanocrystalline catalyst is that it has high catalytic activity and can effectively separate the catalyst in the reaction system under the action of magnets. The details of this thesis are as follows: 1. CuII-CMC-Fe3O4 catalyst was prepared by the exchange of CuII-CMC-Fe3O4 with CuII-CMC-Fe3O4 magnetic nanocomposites and CuAAC. The results show that the catalyst can efficiently catalyze benzyl halides, sodium azide and terminal alkynes under mild conditions, and the catalyst and product can be easily separated and recycled by magnets. The prepared Carboxymethylcellulose- Fe3O4 magnetic nanocomposites and palladium chloride were reduced by ion exchange to obtain PD _ 0R _ (10) / C _ (r) Fe _ 3O _ 4 catalyst for the Suzuki cross-coupling reaction of halogenated aromatics and aryl boric acid. The results show that the reaction can be completed efficiently in a short time, with high yield, mild reaction conditions, good stability of catalyst and easy recovery and reuse under the action of permanent magnet.
【学位授予单位】：暨南大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TB33;O621.251

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