基于多肽和温敏聚合物的光交联囊泡的制备及表征（英文）

发布时间：2018-07-13 13:06

【摘要】：解决聚合物囊泡降解性和稳定性的矛盾是一个重要问题。本文通过可逆加成断裂链转移(RAFT)聚合和开环聚合(ROP)合成了一种聚[(N-异丙基丙烯酰胺-无规-7-(2-甲基丙烯酰氧基乙氧基)-4-甲基香豆素)-嵌段-(L-谷氨酸)][P(NIPAM_(45)-stat-CMA_5)-b-PGA_(42)]的两亲嵌段共聚物。囊泡膜由温敏性的聚N-异丙基丙烯酰胺(PNIPAM)和可光交联聚7-(2-甲基丙烯酰氧基乙氧基)-4-甲基香豆素(PCMA)组成。由囊泡膜向内外舒展的聚谷氨酸(PGA)链使囊泡稳定分散在水中,并且可进一步官能化。透射电子显微镜(TEM)和动态光散射(DLS)表征证实了囊泡的形貌和尺寸分布。本研究为制备基于多肽共聚物的可降解温敏囊泡提供了一个范例,并有望在纳米生物医药领域得到应用。
[Abstract]:It is an important problem to solve the contradiction between the degradability and stability of polymer vesicles. An amphiphilic block copolymer of [(N- isopropylacrylamide-random -7- (2-methacryloxy ethoxy) -4- methylcoumarin)-block-(L- glutamic acid)] [P (NIPAM45) -stat-CMA5) -b-PGA( 42)] was synthesized by reversible addition chain transfer (raft) polymerization and ring opening polymerization (ROP). The vesicle membrane consists of temperature sensitive poly (N isopropyl acrylamide) (PNIPAM) and photocrosslinked poly (7-(2 methacryloxy ethoxy) 4 methyl coumarin (PCMA). The polyglutamic acid (PGA) chain extending from the vesicle membrane to the outside made the vesicle stable and dispersed in water and could be further functionalized. The morphology and size distribution of vesicles were confirmed by transmission electron microscopy (TEM) and dynamic light scattering (DLS). This study provides an example for the preparation of biodegradable thermo-sensitive vesicles based on polypeptide copolymers and is expected to be applied in the field of nano-biomedicine.
【作者单位】：同济大学材料科学与工程学院高分子材料系;同济大学附属上海市第十人民医院;
【基金】：supported by the National Natural Science Foundation of China(21374080,21674081,21611130175) Shanghai International Scientific Collaboration Fund,China(15230724500) Shanghai 1000 Talents Plan Fundamental Research Funds for the Central Universities,China(0500219211,1500219107)~~
【分类号】：O631

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