手性磷酸催化己内酯的动力学拆分
发布时间：2018-07-21 17:53
【摘要】：以动力学拆发的方式得到手性己内脂的方法多以脂肪酶为催化剂,而酶催化具有单一的底物范围且价格较为昂贵的缺点,所以发展其他催化方式仍旧需要探究。报道了首例以手性磷酸作为催化剂,甲苯为溶剂,苄醇为亲核试剂在0℃下对6-取代七元环内酯进行动力学拆分,能够以中等的对映选择性得到手性己内酯,并且具有较广泛的底物范围。该方法具有反应条件简单温和的优点,弥补了酶催化底物范围窄且催化剂昂贵的缺点。
[Abstract]:Lipase is used as catalyst to obtain chiral hexanolipid by kinetic disassembly, and enzyme catalysis has the disadvantages of single substrate range and expensive, so it is still necessary to explore other catalytic methods. The first case of chiral phosphoric acid as catalyst, toluene as solvent, benzyl alcohol as nucleophile reagent for kinetic resolution of 6-substituted heptylcyclolactone at 0 鈩，
本文编号：2136315
[Abstract]:Lipase is used as catalyst to obtain chiral hexanolipid by kinetic disassembly, and enzyme catalysis has the disadvantages of single substrate range and expensive, so it is still necessary to explore other catalytic methods. The first case of chiral phosphoric acid as catalyst, toluene as solvent, benzyl alcohol as nucleophile reagent for kinetic resolution of 6-substituted heptylcyclolactone at 0 鈩，
本文编号：2136315
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