自由基诱导的水溶液中氟西汀的降解:脉冲辐解及稳态辐照研究（英文）

发布时间：2018-11-11 00:16

【摘要】：本文运用脉冲辐解探究了不同自由基与药物氟西汀(FLX)之间的反应。羟基自由基(?OH)与FLX反应生成苯环上的羟基加成物,而硫酸根阴离子自由基(SO_4?~-)则通过单电子氧化FLX生成苯阳离子自由基,该中间产物再进一步与水反应生成苯环上的羟基加成物。本研究测定了三种自由基?OH,水合电子(e_(aq)~-)以及SO_4?~-与FLX反应的反应速率常数分别为:7.8×10~9,2.3×10~9和1.1×10~9mol?L~(-1)?s~(-1)。本文还运用电子束辐照技术探究了不同辐照条件下的FLX降解效果,结合HPLC和紫外可见光谱仪进行分析。在N_2O和空气饱和的两种条件下,FLX溶液经1.5 k Gy辐照后降解效率均达到90%以上,而N_2饱和条件下,加入0.1 mol?L~(-1)的叔丁醇的FLX溶液经1.5 k Gy辐照后仅有43%分解。此外,酸性和中性条件下FLX的降解效率均大于碱性条件下的。结果阐明了饱和空气的FLX溶液在中性条件下的降解效果最佳,且?OH诱导的反应比SO_4?~-更有利于FLX的分解。本研究期望对于进一步探究FLX的降解反应提供有益的帮助。
[Abstract]:The reaction between different free radicals and fluoxetine (FLX) was studied by pulse radiolysis. Hydroxyl radical (? OH) reacts with FLX to form hydroxyl adduct on benzene ring, while sulfate anion radical (SO_4?~-) produces benzene cationic radical by single electron oxidation of FLX. The intermediate product further reacts with water to form hydroxyl adducts on benzene ring. In this study, the reaction rate constants of three kinds of free radicals, OH, hydrated electrons (e-) and SO_4?~- and FLX, were determined as 7.8 脳 10 ~ (9) C ~ (2.3 脳 10 ~ (-1) and 1.1 脳 10 ~ (9) mol / L ~ (-1)? s ~ (-1), respectively. The degradation effect of FLX under different irradiation conditions was investigated by electron beam irradiation technique. The results were analyzed by HPLC and UV-Vis spectrometer. The degradation efficiency of FLX solution was more than 90% after 1.5 k Gy irradiation under the condition of N _ 2O and air saturation, while that of N _ 2 saturated was more than 90%. The FLX solution with 0.1 mol?L~ (-1) tert butanol was irradiated with 1.5 k Gy and only 43% was decomposed. In addition, the degradation efficiency of FLX in acidic and neutral conditions was higher than that in alkaline condition. The results showed that the FLX solution in saturated air had the best degradation efficiency under neutral conditions, and that the reaction induced by OH was more favorable to the decomposition of FLX than that of SO_4?~-. This study is expected to be helpful to further explore the degradation reaction of FLX.
【作者单位】：上海大学环境与化学工程学院;中国科学院上海应用物理研究所;中国科学院大学;
【基金】：supported by the National Natural Science Foundation of China(21173252,41430644,11675098)~~
【分类号】：X703;O644.2

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