地不容生物碱成分研究
发布时间：2018-12-06 14:31
【摘要】：为了研究地不容的生物碱成分,采用硅胶柱层析和Sephadex LH-20柱层析进行化合物的分离纯化,采用HRESIMS,NMR以及比旋光度测定等方法对化合物结构进行鉴定。从地不容中分离鉴定了7个化合物,包括3个吗啡型生物碱:青藤碱(1),sinomenine N-oxide(2)和青风藤碱(3);4个原小檗碱型生物碱:四氢巴马汀(4),紫堇单酚碱(5),千金藤定碱(6)和异紫堇单酚碱(7)。其中化合物2和7为首次从地不容中分离得到,化合物3对乙酰胆碱酯酶具有明显的抑制作用(IC50=3.03μM)。
[Abstract]:In order to study the alkaloids, the compounds were separated and purified by silica gel column chromatography and Sephadex LH-20 column chromatography. The structures of the compounds were identified by HRESIMS,NMR and specific spectrophotometry. Seven compounds, including three morphine-type alkaloids, sinomenine (1), sinomenine N-oxide (2) and sinomenine (3), were isolated and identified from Dianadine. Four proto-berberine alkaloids: tetrahydropalmatine (4), Corydalis monophenol (5), Qianjinding (6) and isocorydine (7). Compounds 2 and 7 were isolated from ground exclusion for the first time. Compound 3 has obvious inhibitory effect on acetylcholinesterase (IC50=3.03 渭 M).
【作者单位】： 云南农业大学基础与信息工程学院;云南大学化学科学与工程学院;
【基金】：国家自然科学基金项目(81460648)资助
【分类号】：O629.3
本文编号：2366178
[Abstract]:In order to study the alkaloids, the compounds were separated and purified by silica gel column chromatography and Sephadex LH-20 column chromatography. The structures of the compounds were identified by HRESIMS,NMR and specific spectrophotometry. Seven compounds, including three morphine-type alkaloids, sinomenine (1), sinomenine N-oxide (2) and sinomenine (3), were isolated and identified from Dianadine. Four proto-berberine alkaloids: tetrahydropalmatine (4), Corydalis monophenol (5), Qianjinding (6) and isocorydine (7). Compounds 2 and 7 were isolated from ground exclusion for the first time. Compound 3 has obvious inhibitory effect on acetylcholinesterase (IC50=3.03 渭 M).
【作者单位】： 云南农业大学基础与信息工程学院;云南大学化学科学与工程学院;
【基金】：国家自然科学基金项目(81460648)资助
【分类号】：O629.3
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1 陆云阳;汤海峰;高凯;王啸洋;张伟;马宁;;交让木的生物碱成分研究[J];中南药学;2014年04期
，本文编号：2366178
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