山土瓜和疣叶暗罗两种药用植物化学成分的研究

发布时间：2018-12-11 01:12

【摘要】：本文对两种云南产药用植物山土瓜(Ipomoea hungaiensis)和疣叶暗罗(Polyalthia verrucipes)的化学成分进行了研究,分离后经过谱学分析鉴定25个化合物。通过溶剂提取,之后利用各种柱层析和谱学分析的方法,从山土瓜的根部中分离得到8个化合物,谱学分析(~1H-NMR,~(13)C-NMR)鉴定其结构分别为:triumfettoside Ic(1),3β-friedlinol(2),lupeol 3-(3'R-hydroxy)-octadecanoate(3),6,7-dihydroxycoumarin(4),octadecyl caffeate(5),syringic acid(6),β-sitosterol-β-D-glucopyranoside(7),β-谷甾醇(8),其中,化合物1,3,6首次从山土瓜中分离得到。通过同样的方法从疣叶暗罗的枝叶中分离并鉴定得到17个化合物,通过波谱解析的方法鉴定其结构,包括木脂素、甾体、黄酮、萜类化合物、简单芳香族化合物等类型,分别为:7,3',4'-trimethylquercetin(9),5,4′-dihydroxy-3,7,3′-trimethoxyflavone(10),3,5-dinydroxy-6,7,3',4'-etramethoxyflavone(11),4'-hydroxy-3,5,7,3'-tetramethoxyflavone(12),3,7-O-dimethylquercetin(13),quercetin(14),butin(15),miliusol(16),4-hydroxy-9-methoxy-dihydromiliusol(17),ursolic acid(18),豆甾醇(19),(+)-syringaresinol(20),(6R,10R)-6,10,14-trimethyl-2-pentadecanone(21),ethyl gallate(22),protocatechuic acid methyl ester(23),methyl gallate(24),4-methoxybenzene-1,3-diol(25)。其中化合物16-17,21和25为首次在暗罗属中分离得到。最后,综述部分归纳了旋花科番薯属植物化学成分及药理作用和生物活性的研究进展。
[Abstract]:In this paper, the chemical constituents of (Ipomoea hungaiensis) and (Polyalthia verrucipes) from two medicinal plants of Yunnan were studied. After being separated, 25 compounds were identified by spectroscopic analysis. After solvent extraction, eight compounds were isolated from the roots of Melon by column chromatography and spectroscopic analysis. The structures of the compounds were identified as: triumfettoside Ic (1 by spectral analysis (~ 1H-NMR13 C-NMR). 3 尾-friedlinol (2), lupeol 3- (3'R-hydroxy)-octadecanoate (3), 6), lupeol 7-dihydroxycoumarin (4), octadecyl caffeate (5), syringic acid (6), 尾-sitosterol- 尾-D-glucopyranoside (7), 尾-sitosterol (8), in which, compound 1: 3, 6. Through the same method, 17 compounds were isolated and identified from the branches and leaves of Amelia verruca. Their structures were identified by spectroscopic analysis, including lignans, steroids, flavonoids, terpenoids, simple aromatic compounds, and so on. The results were as follows: (1) -trimethylquercetin (9), (5) -dihydroxy-3 (3) -trimethoxyflavone (10), (3) 5-dinydroxy-6 (7), (4) -etramethoxyflavone (11), (4) -hydroxy-35 (7) -tetramethoxyflavone (12), 37-O-dimethylquercetin (13), quercetin (14), respectively. Butin (15), miliusol (16), 4-hydroxy-9-methoxy-dihydromiliusol (17), ursolic acid (18), 19), ()-syringaresinol (20), (6RX 10R) -6Con 101014-trimethyl-2-pentadecanone (21), ethyl gallate (22), protocatechuic acid methyl ester (23), Methyl gallate (24, 4-methoxybenzene-1, 3-diol (25). Among them, compounds 16-17, 21 and 25 were isolated for the first time in the genus Amranthus. Finally, the research progress of chemical constituents, pharmacological actions and biological activities of sweet potato plants in the family Scopodiaceae was summarized.
【学位授予单位】：云南师范大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O657;R284.1

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