萜类化合物的合成生物学研究进展

发布时间：2018-12-14 20:34

【摘要】：萜类化合物是种类最多的一类天然产物,具有抗癌、抗过敏等多种生物活性,在食品、日化、医疗等领域受到广泛关注,展现了巨大的应用潜力和广阔的市场前景。近年来,研究人员采用功能基因组学和代谢组学技术对不同萜类的合成途径进行了深入研究,为萜类的合成生物学研究提供了大量的数据支撑。目前,已经通过合成生物学方法构建出萜类高产的酵母工程菌株,实现了多种目标产物的高效生产,有效提高了萜类的总体生产水平。因此,采用合成生物学策略合成萜类化合物,有望成为植物源萜类生产的有效技术手段。首先介绍了合成生物学概念,进而总结了植物源萜类的重要功能和应用领域,并简述了不同萜类的合成途径,归纳了现有的萜类生产方式,然后深入探讨了萜类生物合成的设计策略,最后以几种常见的萜类为例,详细论述了不同萜类的合成生物学的研究进展。
[Abstract]:Terpenoids are the most kinds of natural products with many biological activities such as anti-cancer and anti-allergies. Terpenoids have attracted extensive attention in the fields of food, daily chemistry, medicine and so on, showing great application potential and broad market prospects. In recent years, functional genomics and metabonomics techniques have been used to study the synthesis pathways of different terpenoids, which provides a large amount of data support for the study of synthetic biology of terpenes. At present, a yeast engineering strain with high yield of terpenes has been constructed by synthetic biological method, which has realized the efficient production of various target products and effectively improved the overall production level of terpenoids. Therefore, the synthesis of terpenoids by synthetic biology is expected to be an effective technique for the production of plant terpenoids. In this paper, the concept of synthetic biology is introduced, and the important functions and application fields of plant terpenoids are summarized, and the synthesis pathways of different terpenoids are summarized, and the existing terpenoid production modes are summarized. Then, the design strategy of terpene biosynthesis is discussed in depth. Finally, taking several common terpenoids as examples, the research progress of synthetic biology of different terpenoids is discussed in detail.
【作者单位】：中国农业科学院农产品加工研究所;

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