白喉乌头中二萜生物碱及其拒食活性研究
发布时间：2019-03-02 08:27
【摘要】：从白喉乌头(Aconitum leucostomum Vorosch.)中分离得到13个二萜生物碱,采用HR-ESI-MS,1D NMR和2D NMR等波谱技术确定了它们的结构.其中一个为新的C_(18)二萜生物碱:刺乌宁,其余为已知化合物.同时考察了其中12个化合物对甜菜夜蛾3龄幼虫的拒食活性,结果表明化合物氨茴酰基牛扁碱和东乌头定的活性较好(EC_(50)1mg/cm~2),其次是N-acetylsepaconitine,赣乌碱和N-去乙酰高乌甲素(EC_(50)2 mg/cm~2).
[Abstract]:(Aconitum leucostomum Vorosch.) from diphtheria aconitum Thirteen diterpene alkaloids were isolated and their structures were determined by HR-ESI-MS,1D NMR and 2D NMR spectra. One of them is a new C _ (18) diterpene alkaloid, spinonine, and the others are known compounds. At the same time, the antifeedant activity of 12 compounds against the third instar larvae of Spodoptera exigua was studied. The results showed that the compounds EC_ (50) 1mg/cm~2 were the best, followed by N _ (acetylsepaconitine), and the antifeedant activity of these compounds to the larvae of Spodoptera exigua was higher than that of Aconitine (50) 1mg/cm~2. Ganyuline and N-deacetygouridine (EC_ (50) 2 mg/cm~2).
【作者单位】： 西南交通大学生命科学与工程学院;西南交通大学材料科学与工程学院;西华师范大学化学化工学院;
【基金】：国家自然科学基金(No.81402803) 四川省小分子天然药物创新团队(No.15TD0048) 四川省教育厅项目(No.15ZB0140) 中央高校基本科研业务费专项(No.2682017QY04)资助项目~~
【分类号】：O629.3
，
本文编号：2432879
[Abstract]:(Aconitum leucostomum Vorosch.) from diphtheria aconitum Thirteen diterpene alkaloids were isolated and their structures were determined by HR-ESI-MS,1D NMR and 2D NMR spectra. One of them is a new C _ (18) diterpene alkaloid, spinonine, and the others are known compounds. At the same time, the antifeedant activity of 12 compounds against the third instar larvae of Spodoptera exigua was studied. The results showed that the compounds EC_ (50) 1mg/cm~2 were the best, followed by N _ (acetylsepaconitine), and the antifeedant activity of these compounds to the larvae of Spodoptera exigua was higher than that of Aconitine (50) 1mg/cm~2. Ganyuline and N-deacetygouridine (EC_ (50) 2 mg/cm~2).
【作者单位】： 西南交通大学生命科学与工程学院;西南交通大学材料科学与工程学院;西华师范大学化学化工学院;
【基金】：国家自然科学基金(No.81402803) 四川省小分子天然药物创新团队(No.15TD0048) 四川省教育厅项目(No.15ZB0140) 中央高校基本科研业务费专项(No.2682017QY04)资助项目~~
【分类号】：O629.3
，
本文编号：2432879
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