拆分手性化合物色谱填料的研究进展

发布时间：2019-05-17 01:48

【摘要】：手性是自然界的一种普遍的现象。不同手性对映体的生理活性差异较大,对手性化合物进行拆分具有十分重要的意义。随着生命、化学、材料的发展,人们对手性化合物的研究也日益深入,色谱法在拆分手性化合物中得到了越来越广泛的应用。作为色谱柱的"心脏",色谱填料的选择成为了色谱法拆分手性化合物的关键,拆分手性化合物的色谱填料成为人们关注的热点。目前使用的填料主要包括多糖类手性色谱填料、大环手性色谱填料、手性配体交换色谱填料、分子印迹聚合物色谱填料、分子印迹冰胶聚合物色谱填料、"刷型"手性色谱填料、手性金属-有机骨架色谱填料、硅胶键合环果糖色谱填料、蛋白质类手性色谱填料、小粒径色谱填料、免疫亲和色谱填料。本文就拆分手性化合物的色谱填料的研究进展进行综述。
[Abstract]:Chiral is a common phenomenon in nature. The physiological activities of different chiral enantiomers are quite different, so it is of great significance to split chiral compounds. With the development of life, chemistry and materials, chiral compounds have been studied more and more deeply. Chromatography has been more and more widely used in the resolution of chiral compounds. As the "heart" of chromatographic columns, the selection of chromatographic fillers has become the key to the resolution of chiral compounds by chromatography, and the chromatographic fillers for the resolution of chiral compounds have become the focus of attention. At present, the fillers mainly include polysaccharide chiral chromatographic packing, macrocyclic chiral chromatographic packing, chiral ligand exchange chromatographic packing, molecular imprinted polymer chromatographic packing, molecular imprinted ice gel polymer chromatographic packing. Brush chiral chromatographic packing, chiral metal-organic skeleton chromatographic packing, silica gel bonded cyclic fructose chromatography packing, protein chiral chromatographic packing, small particle size chromatographic packing, immunoaffinity chromatographic packing. In this paper, the research progress of chromatographic fillers for the resolution of chiral compounds is reviewed.
【作者单位】：北京中医药大学中药学院;北京中医药大学中医学院;北京中医药大学北京中医药研究院;
【基金】：国家自然科学基金(81473338):基于特异性敲除技术的葛根素和黄芩苷与葛根芩连汤功效关联机制的研究
【分类号】：O652.6

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