聚多巴胺类纳米粒子的制备与表征及其在界面聚合复合膜中的应用探索

发布时间：2018-03-13 04:00

本文选题：多巴胺　切入点：聚多巴胺类纳米粒子　出处：《浙江大学》2015年硕士论文　论文类型：学位论文

【摘要】：近年来的仿生学研究发现,海洋中贻贝的足腺细胞能够分泌出一种具有超强粘附性能的足丝蛋白,这种蛋白在潮湿环境下也可以迅速地固化成足丝,将贻贝牢牢固定在礁石、船体、绳缆等固体的表面。研究者们发现,贻贝足丝的强附着能力来源于足丝蛋白中的多巴(L-DOPA)和赖氨酸残基,多巴胺兼有L-DOPA的邻苯二酚结构和赖氨酸的氨基,能在弱碱性水溶液条件下通过多层次的自聚-组装形成纳米结构,并进一步在固体材料表面沉积,形成紧密附着的涂层。因此,多巴胺被广泛用作儿茶酚化学的模型化合物。本课题组以前的研究发现,多巴胺不仅能够在材料表面沉积形成涂层,也能在溶液中形成纳米粒子(NPs)。为稳定制备尺寸可控的多巴胺类NPs,本论文系统地研究了制备条件对多巴胺类NPs尺寸和形貌的影响,探讨了NPs的基本性质及其形成机理。在此基础上,尝试将所制备的PDA NPs用于界面聚合反渗透(RO)复合膜的改性,考察界面聚合反应的水相中PDA NPs的引入对RO膜渗透性、选择性、表面亲水性的影响,为PDA NPs在膜材料制备中的应用提供参考。主要研究工作主要分为以下两个部分：(1)基于在氧化条件下,多巴胺等儿茶酚衍生物可以通过自聚-组装行为形成聚多巴胺类纳米粒子,本部分工作采用溶液氧化法,通过系统地调节溶质浓度、反应温度、反应介质、反应时间、氧化剂种类等实验条件,在不同反应条件下合成一系列尺寸不同,分散性良好的聚多巴胺类纳米粒子,并利用紫外-可见分光光度计、粒度分析仪、透射电镜、pH自动校正计、傅里叶-变换红外光谱仪等观测纳米粒子的形貌尺寸和化学组成,最后结合本研究结果和相关文献报道,探讨聚多巴胺类纳米粒子的形成机理和实验条件,为制备粒径可控、均匀稳定的聚多巴胺类纳米粒子提供了数据资料,且为掌握聚多巴胺类自聚组装体多层次结构和聚多巴胺类多功能性应用提供实验依据。(2) PDANPs中富含氨基、亚氨基、邻苯二酚等功能基团,这些功能基团在一定条件下可以发生迈克尔加成反应、席夫碱反应、酰胺化反应和酯化反应等,因此PDA NPs表面容易进行功能化修饰,且在聚合物材料中具有优异的界面相容性和分散性。基于此,本文将PDA NPs引入到界面聚合复合膜中。为界面聚合复合膜的表面亲水化改性提供了新的契机。本部分工作首先用界面聚合法制备聚酰胺复合膜,然后将所制备的PDA NPs引入到界面聚合复合膜的功能层中,通过系统地调节两相单体浓度、反应时间、PDA NPs浓度等实验条件,分别利用红外光谱、SEM、接触角测定仪、通量测量仪等测量了改性前后膜表面的化学组成、形貌、截盐率、通量以及亲水性,考察聚酰胺复合膜膜性能的影响因素,同时为聚合物复合膜表面的亲水化改性提供新的思路。
[Abstract]:Bionics research in recent years found that the marine mussel foot gland cells can secrete a kind of super adhesion foot proteins, the protein can also rapidly solidified into filaments in a damp environment, will be firmly fixed in the mussel reefs, hull, rope and other solid surface. The researchers found. Byssus strong adhesion ability from foot proteins in Doba (L-DOPA) and lysine residues, both L-DOPA and dopamine catechol structure of the amino group of lysine, through self polymerization assemble into nano hierarchical structure in alkaline aqueous solution conditions, and further in the surface of solid material deposition, forming a coating adhered tightly. Therefore, dopamine is widely used as a model compound of Catechol chemistry. The research group previously found that dopamine can form a coating deposited on the material surface, but also in the solution The formation of nanoparticles (NPs). For the preparation of stable NPs dopaminergics with controllable size, this paper systematically studied the effect of preparation conditions on the size and morphology of dopamine NPs, discusses the basic properties of NPs and its formation mechanism. Based on this, try to be prepared PDA NPs for interfacial polymerization of reverse osmosis (RO) modified composite film, the introduction of PDA NPs polymerization in aqueous phase on the interface of RO membrane permeability, selectivity, hydrophilic surface, provide a reference for the application of NPs in the preparation of PDA membrane materials. The main research work is divided into the following two parts: (1) based on under oxidizing conditions, dopamine and other catechol derivatives can polydopamine nanoparticle by self - assembly behavior of poly formation, this part by solution oxidation method, by systematically adjusting the solute concentration, reaction temperature, reaction medium, reaction time, oxidant The experimental conditions, the synthesis of a series of different sizes under different reaction conditions, dispersed polydopamine nanoparticle has good adhesion, and by using UV VIS spectrophotometer, particle size analyzer, transmission electron microscopy, pH automatic correction, morphology and chemical composition of Fu Liye transform infrared spectrometer observation of nanoparticles, finally combined with the the research results and relevant literature, to explore the formation mechanism and experimental conditions of polydopamine nanoparticle preparation, controllable particle size, provided the data of uniform and stable polydopamine class nanoparticles, and master the polydopamine self assembly multilayer structure and poly polydopamine class to provide experimental basis for multi functional application (. 2) PDANPs rich in amino, imino, catechol functional groups, these functional groups can be Michael addition reaction under certain conditions, Schiff reaction, amide Chemical reaction and esterification reaction, so the PDA NPs surface can be easily modified, and has excellent interfacial compatibility and dispersibility in polymeric materials. Based on this, this paper will PDA NPs into the interfacial polymerization in the composite films. The interface for hydrophilic surface modification of polymer composite film provides a new opportunity. This part starts with the preparation of polyamide composite membrane interface polymerization method, then the prepared PDA NPs into the interface layer polymerization composite membrane, by systematically adjusting the two monomer concentration, reaction time, experimental conditions of PDA NPs concentration, respectively, using infrared spectroscopy, SEM, contact angle measurement, flux measuring instrument measuring the chemical modification of the membrane surface morphology before and after cutting, rate of salt flux and hydrophilic, study the factors affecting performance of polyamide composite membrane, and polymer composite film surface hydrophilic modification provided A new idea.

【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TQ051.893

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