挤出成型结合造孔剂法制备多孔磷酸钙生物陶瓷及其表征

发布时间：2018-03-14 00:18

本文选题：无机陶瓷材料　切入点：多孔陶瓷　出处：《中国科技论文》2017年10期 　论文类型：期刊论文

【摘要】：针对多孔磷酸钙生物陶瓷难以平衡力学性能与孔隙率和孔连通性的关系问题,采用结合挤出成型法和造孔剂法制备了三维连通孔磷酸钙生物陶瓷。使用X射线衍射仪和扫描电镜对多孔磷酸钙生物陶瓷的物相和形貌进行了表征,测试了材料的抗压强度和孔隙率,评价了细胞学性能。测试结果表明:所制备的多孔磷酸钙生物陶瓷的物相为纯相的β相磷酸三钙;挤出形成的直通宏孔规则排列,孔径约为400μm;在三维连通孔磷酸钙生物陶瓷的直通宏孔孔壁上随机分布着横向连通孔,这些横向连通孔将相邻的直通宏孔贯通起来,形成三维连通的孔结构;单纯直通孔和三维连通孔磷酸钙生物陶瓷的孔隙率分别为60%和70%,抗压强度(平行于直通宏孔方向)分别为20和5MPa。细胞学实验表明,所制备的多孔磷酸钙生物陶瓷具有良好的细胞黏附能力,三维连通孔磷酸钙生物陶瓷比单纯直通孔磷酸钙生物陶瓷具有更强的细胞增殖能力,但成骨分化能力低于单纯直通孔磷酸钙生物陶瓷。因此,结合挤出成型法和造孔剂法是1种制备具有三维连通、高抗压强度多孔磷酸钙生物陶瓷的有效方法。
[Abstract]:In view of the relationship between the imbalanced mechanical properties of porous calcium phosphate bioceramics and porosity and pore connectivity, Three-dimensional porous calcium phosphate bioceramics were prepared by combining extrusion molding method and pore making agent method. The phase and morphology of porous calcium phosphate bioceramics were characterized by X-ray diffraction and scanning electron microscopy. The compressive strength and porosity of the materials were tested, and the cytological properties were evaluated. The results showed that the phase of the porous calcium phosphate bioceramics was pure phase 尾 -tricalcium phosphate, and the straight through macropores were arranged regularly. The pore size is about 400 渭 m, and the transverse connected pores are randomly distributed on the wall of the straight through macro holes of the three-dimensional connected porous calcium phosphate bioceramics, which make the adjacent straight through macro holes through and form a three-dimensional connected pore structure. The porosity of pure through pore and three dimensional connected pore calcium phosphate bioceramics were 60% and 70, respectively, and the compressive strength (parallel to the direction of straight through macro pore) were 20 and 5 MPa, respectively. The porous calcium phosphate bioceramics have good cell adhesion, and the three-dimensional porous calcium phosphate bioceramics have stronger cell proliferation ability than the straight through porous calcium phosphate bioceramics. However, the osteogenic differentiation ability is lower than that of pure through pore calcium phosphate bioceramics. Therefore, the combination of extrusion molding method and pore making agent method is an effective method for the preparation of porous calcium phosphate bioceramics with three-dimensional connectivity and high compressive strength.
【作者单位】：华南理工大学材料科学与工程学院;生物医学材料与工程教育部重点实验室;广东工业大学机电工程学院;国家人体组织功能重建工程技术研究中心;
【基金】：高等学校博士学科点专项科研基金资助项目(20130172110006) 广州市珠江科技新星项目(201710010149)
【分类号】：TQ174.6

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