咪唑-1-乙酸壳聚糖支架仿生合成羟基磷灰石

发布时间：2018-03-28 10:10

  本文选题：咪唑--乙酸壳聚糖支架　切入点：仿生合成　出处：《化工新型材料》2017年06期

【摘要】：以咪唑-1-乙酸改性壳聚糖(IACS)为生物支架,在模拟体液(SBF)中调控仿生合成羟基磷灰石(HA)。探讨了支架类型、陈化时间、钙离子(Ca~(2+))浓度等因素对IACS生物支架在SBF中调控合成HA的影响,并通过X射线衍射仪、傅里叶变换红外光谱分析仪、场发射扫描电子显微镜等对合成的HA进行表征。结果表明,在SBF中,以500KDIACS1为生物模板支架,Ca~(2+)离子浓度为0.10mol/L,反应温度为37℃,随着陈化时间从12h延长至72h,HA从球型颗粒向针状转化且分散越均匀,与自然骨中的HA相类似。因此,利用IACS生物支架调控合成的HA有望在硬组织修补与替换、药物缓释等生物医学工程领域得到广泛应用,也为仿生合成其他生物矿物提供借鉴。
[Abstract]:Imidazole-1-acetic acid modified chitosan (IACSs) was used as a biological scaffold to regulate the synthesis of hydroxyapatite in simulated humoral fluid (SBF). The type of scaffold and aging time were discussed. The effects of calcium concentration on the synthesis of HA in IACS scaffolds were investigated by X-ray diffractometer, Fourier transform infrared spectroscopy and field emission scanning electron microscope. In SBF, the concentration of 500KDIACS1 was 0.10 mol / L and the reaction temperature was 37 鈩，

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