新型聚砜手性膜的制备及其在色氨酸手性拆分中的应用

发布时间：2018-04-16 11:18

本文选题：十二酰基-β-环糊精 + 聚砜膜　；参考：《中国药科大学学报》2017年01期

【摘要】：为了研制新型聚砜手性膜,采用十二酰氯与β-环糊精反应,制备一种新型的十二酰基-β-环糊精,然后将其添加到聚砜铸膜液中,采用浸入沉淀相转化法制备十二酰基-β-环糊精/聚砜手性膜。分别考察十二酰基-β-环糊精的添加量对膜的纯水通量、牛血清白蛋白(BSA)截留率和手性拆分性能的影响。膜的形态采用扫描电子显微镜进行表征。实验结果表明,随着十二酰基-β-环糊精含量的增加,膜的孔径发生变化,膜的支撑层中出现指状孔结构。因此,膜的水通量显著上升而截留率略有降低。当十二酰基-β-环糊精的添加量在2%~3.5%范围内,随着十二酰基-β-环糊精添加量的增加,过滤次数相同时,对映体过量百分数(ee,%)逐渐增加。利用所制备的十二酰基-β-环糊精聚砜/手性膜,采用多级过滤装置最终实现了外消旋色氨酸的完全分离。
[Abstract]:In order to prepare a novel poly (sulfone) chiral membrane, a novel dodecyl 尾 -cyclodextrin was prepared by the reaction of dodecyl chloride with 尾 -cyclodextrin.Dodecyl-尾-cyclodextrin / polysulfone chiral membranes were prepared by immersion precipitation phase inversion method.The effects of addition of dodecyl 尾-cyclodextrin on pure water flux, bovine serum albumin (BSA) retention and chiral resolution were investigated.The morphology of the film was characterized by scanning electron microscope (SEM).The experimental results show that with the increase of dodecyl 尾 -cyclodextrin content, the pore size of the membrane changes, and the finger-like pore structure appears in the supporting layer of the membrane.Therefore, the water flux of the membrane increased significantly and the retention rate decreased slightly.When the amount of dodecyl-尾-cyclodextrin was in the range of 2 ~ 3. 5%, with the increase of the amount of dodecyl-尾-cyclodextrin, the percentage of excess enantiomer increased with the increase of the amount of dodecyl-尾-cyclodextrin.Using the dodecyl 尾-cyclodextrin polysulfone / chiral membrane, the complete separation of racemic tryptophan was achieved by using a multistage filtration device.
【作者单位】：中国药科大学分析化学教研室;
【分类号】：TQ051.893

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