三巯基丙酸修饰的Mn掺杂ZnS量子点的合成及分析应用

发布时间：2018-05-08 12:38

本文选题：量子点 + ZnS　；参考：《山西大学》2015年硕士论文

【摘要】：量子点是粒径为1～100 nm范围内的半导体纳米晶,呈现宽而连续的激发光谱,窄而对称的发射光谱,且光稳定性好,另外,还可通过调节量子点的尺寸大小得到不同波长的发射光。目前,锌类量子点由于其低毒性受到了广泛的关注,同时通过给锌类量子点掺杂微量的过渡金属离子,将会大大提高量子产率。此外,在量子点表面修饰一些有机小分子,就可以得到水溶性、生物相容性较好的掺杂型锌类量子点。这些优异的性质使得量子点在化学、生物学、材料学及医药学等领域有着广泛的研究和应用。近年来,运用量子点的荧光分析法为定量测定药物分子开辟了一条新颖、快速、价格低廉且灵敏便捷的途径,并且展现出了潜在的应用前景。本论文旨在研究Mn掺杂ZnS量子点的光谱性能并探索其在分析检测方面的应用。主要研究内容如下：第一章概述了量子点的定义、性质、合成方法及在分析检测领域的应用,并简单介绍了掺杂量子点的优势、类型及合成方法。第二章运用共沉淀法制备ZnS:Mn量子点,通过TEM、XRD、DLS、红外光谱、紫外吸收光谱、荧光光谱等手段分别从结构、形貌、尺寸分布、光学性质等这几方面对合成的样品进行了表征,结果表明：合成的量子点呈球形、粒径分布均匀、呈立方晶型、光谱强度好、水溶液呈电负性。第三章以MPA为稳定剂,通过共沉淀法合成了Mn掺杂ZnS量子点。考虑到ZnS:Mn量子点独特的双发射特性,即ZnS本体的特征缺陷发射峰和由锰的辐射跃迁而产生的橙色发射峰,以及姜黄素对其特征缺陷发射具有猝灭作用而对橙色发射无影响这一特点,构建了一种简单快速的测定姜黄素的比率荧光方法。该方法的线性范围为0.16-16.9μmol/L,检出限为0.037μmol/L,相关系数为0.9993。第四章运用标准方法LC-MS测定尿样中姜黄素的浓度。比较此法与我们建立的方法,进一步验证构建方法的准确性。
[Abstract]:Quantum dots (QDs) are semiconductor nanocrystals with a particle size of 1 ~ 100 nm. They exhibit broad and continuous excitation spectra, narrow and symmetrical emission spectra and good optical stability. In addition, different wavelengths of emission can be obtained by adjusting the size of quantum dots. At present, zinc quantum dots (QDs) have attracted much attention because of their low toxicity. At the same time, the quantum yield will be greatly improved by doping zinc quantum dots with small amounts of transition metal ions. In addition, doped zinc quantum dots with water solubility and good biocompatibility can be obtained by modifying some organic small molecules on the surface of quantum dots. These excellent properties make quantum dots widely studied and applied in chemistry, biology, materials and medicine. In recent years, the use of quantum dot fluorescence analysis for quantitative determination of drug molecules has opened up a novel, rapid, cheap, sensitive and convenient way, and has shown a potential application prospects. The aim of this thesis is to study the spectral properties of mn doped ZnS quantum dots and to explore their applications in analytical detection. The main research contents are as follows: in the first chapter, the definition, properties, synthesis methods and applications in the field of analysis and detection of quantum dots are summarized, and the advantages, types and synthesis methods of doped quantum dots are briefly introduced. In chapter 2, ZnS:Mn quantum dots were prepared by coprecipitation method. The synthesized QDs were characterized by means of structure, morphology, size distribution, optical properties and so on. The results show that the synthesized QDs are spherical, uniform in size distribution, cubic in shape, good in spectral intensity and electronegativity in aqueous solution. In chapter 3, Mn-doped ZnS quantum dots were synthesized by co-precipitation using MPA as stabilizer. Taking into account the unique double emission characteristics of ZnS:Mn quantum dots, namely, the characteristic defect emission peaks of the ZnS bulk and the orange emission peaks resulting from the radiative transition of manganese, A simple and rapid method for the determination of curcumin ratio fluorescence was developed because curcumin had quenching effect on its characteristic defect emission but had no effect on orange emission. The linear range of the method is 0.16-16.9 渭 mol / L, the detection limit is 0.037 渭 mol / L and the correlation coefficient is 0.9993. In chapter 4, the concentration of curcumin in urine was determined by LC-MS. The accuracy of the method is further verified by comparing this method with the method established by us.
【学位授予单位】：山西大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TQ132.41

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