聚多巴胺修饰的介孔二氧化硅微球的合成及其用于负载左旋薄荷醇凉味剂

发布时间：2018-05-16 03:33

本文选题：介孔二氧化硅 + 聚多巴胺　；参考：《无机材料学报》2017年08期

【摘要】：介孔二氧化硅材料具有巨大的孔隙率、开放的孔道结构、易于改性的孔道表面以及良好的生物相容性,广泛用于药物传递、吸附分离以及催化等领域。本研究通过非极性溶剂辅助共组装法合成了具有较大孔径(6.9 nm)和比表面积(615 m2/g)的介孔二氧化硅微球。采用纳米浇铸的方法,成功地将左旋薄荷醇负载到该材料的孔内。进一步通过界面聚合的方法,在所得微球的表面涂覆一层聚多巴胺(PDA)涂层,从而将薄荷醇封装在微球的孔道内。利用PDA作为半透膜,研究了复合微球在不同温度的空气吹扫下释放薄荷醇的行为,发现在相对适宜的温度下PDA涂层有利于薄荷醇的可控缓慢释放。这些研究结果表明基于聚多巴胺修饰的介孔二氧化硅材料有望用于开发食品和医药等领域的缓释制剂。
[Abstract]:Mesoporous silica materials have great porosity, open pore structure, easy modification of pore surface and good biocompatibility. They are widely used in drug delivery, adsorption, separation and catalysis. In this study, mesoporous silica microspheres with large pore size (6.9 nm) and specific surface area (615 m2 / g) were synthesized by non-polar solvent-assisted co-assembly method. The method of nano-casting was used to successfully load levo-menthol into the pore of the material. Furthermore, the microspheres were coated with polydopamine PDA-coating by interfacial polymerization, and the menthol was encapsulated in the pores of the microspheres. Using PDA as semi-permeable membrane, the release behavior of menthol from composite microspheres under air swept at different temperatures was studied. It was found that the PDA coating at relatively suitable temperature was beneficial to the controlled slow release of menthol. These results suggest that polydopamine-modified mesoporous silica materials are expected to be used in the development of sustained-release formulations in food and medicine.
【作者单位】：广西中烟工业有限责任公司;复旦大学化学系;
【分类号】：TB383.4;TQ127.2

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