青霉素废菌渣微波水解制备复合氨基酸及应用

发布时间：2018-07-01 08:47

  本文选题：废菌渣 + 石膏缓凝剂　； 参考：《化工进展》2017年06期

【摘要】：青霉素废菌渣是制药工业青霉素发酵工序产生的固体废弃物,处理不当会导致环境污染、危及生态。本文以废菌渣为原料,在碱性条件下,采用微波水解方法得到复合氨基酸。将其作为石膏缓凝剂,可以实现废菌渣的安全、高附加值利用。在单因素实验的基础上,以碱浓度、料液比、反应时间、反应温度为考察因素,采用正交实验法确定最佳工艺条件为:碱浓度0.04mol/L,料液比1∶4,微波水解时间10min,温度85℃。借助氨基酸分析仪分析了水解产物的化学组成,利用红外光谱、扫描电镜等手段对缓凝作用(石膏体系)机理进行了分析研究。结果表明:水解物主要是赖氨酸、酪氨酸、半胱氨酸等氨基酸的混合物,其中氨基和羧基官能团参与了钙的配位,形成了钙的复合氨基酸/小肽螯合物,从而延缓了石膏的溶解、水化和结晶过程,使凝结时间延长。
[Abstract]:Penicillin waste bacteria residue is a solid waste produced by penicillin fermentation process in pharmaceutical industry. Improper treatment will lead to environmental pollution and endanger the ecology. In this paper, compound amino acids were obtained by microwave hydrolysis under alkaline conditions from waste bacteria residue. It can be used as gypsum retarder to realize the safety and high value-added utilization of waste bacteria residue. On the basis of single factor experiment, the optimum conditions were determined by orthogonal experiment: alkali concentration 0.04 mol / L, ratio of material to liquid 1: 4, microwave hydrolysis time 10 min, temperature 85 鈩，

本文编号：2087221