组装式微流控系统制备双重包裹微液滴的方法研究

发布时间：2018-06-29 17:12

本文选题：微流控 + 微液滴制备　；参考：《实验力学》2017年02期

【摘要】：介绍了一种组装式微流控系统制备单、双重包裹微液滴的方法。微系统中用三通接头构成T型微流体通道,使得分散相在连续相强烈的剪切力和压力差作用下断裂形成单个微米级液滴。在制备单个微液滴基础上,用毛细管将两个三通接头串联,通过调控三相流量,可产生双重包裹液滴。结合实验结果,分析了流体粘度比对液滴大小的影响,并得出液滴的尺寸与流量比之间的关系式,为制备不同尺寸的液滴提供了参考依据。对制备的样品进行统计分析,结果显示,液滴的多分散性指数均小于3.2%,表明微液滴的高度均匀性。此外,通过调节三相液体的流量不仅可以控制内外层液滴的大小,还可以调节内层包裹液滴的个数。本文提出的制备方法,设备组装拆卸简便,不需表面亲疏水性处理,装置利用率高,产生的单、双重包裹微液滴可满足高通量的测量分析要求。
[Abstract]:A microfluidic system is introduced in this paper. A microfluidic system is prepared by assembling a microfluidic system. In the micro system, a T type micro fluid channel is formed by three connections, which makes the dispersed phase break into a single micrometer droplet under the strong shear force and pressure difference of the continuous phase. On the basis of the preparation of a single microdroplet, a capillary is used to connect two three connections. In series, double package drops can be produced by regulating three phase flow. Combined with experimental results, the influence of fluid viscosity ratio on droplet size is analyzed, and the relationship between the size of droplet size and flow ratio is obtained, which provides reference for preparing different sizes of droplets. The polydispersity index is less than 3.2%, indicating the high uniformity of the microdroplets. In addition, the amount of the inner and outer droplets can be controlled by regulating the flow of the three phase liquid, and the number of the droplets in the inner layer can be adjusted. The preparation method proposed in this paper is simple and easy to disassemble the equipment, without the surface hydrophobicity treatment, and the equipment has high utilization rate. The single and double coated micro droplets can meet the requirements of high flux measurement and analysis.
【作者单位】：中国科学技术大学热科学和能源工程系;广东省软凝聚态物质重点实验室;
【基金】：国家自然科学基金(GG2070000344)资助
【分类号】：O35

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