昆虫杆状病毒组学研究进展

发布时间：2018-09-12 05:59

【摘要】：杆状病毒(baculoviruses)是一类专性感染无脊椎动物的共价闭合双链环状DNA昆虫病毒。由于杆状病毒对环境和人畜无害,其作为生物农药在生物防治方面发挥着重大作用。此外,杆状病毒还可作为一种真核表达载体,广泛用于药物研发、疫苗生产,以及作为基因转移载体用于基因治疗等方面。综述了杆状病毒的基因组学及蛋白质组学研究进展,对阐明病毒的感染机制具有重要意义,并且在此基础上可针对性地对其进行分子改良或开发高效的生物增效剂。
[Abstract]:Baculovirus (baculoviruses) is a class of covalently closed double stranded circular DNA insect viruses that are specifically infected with invertebrates. Baculovirus plays an important role in biological control because it is harmless to environment, human and animal. In addition, baculovirus can be used as an eukaryotic expression vector, widely used in drug development, vaccine production and gene transfer vector for gene therapy. The advances in genomics and proteomics of baculovirus were reviewed in this paper. It is of great significance to clarify the infection mechanism of baculovirus. On the basis of this, molecular modification or development of highly efficient biological synergist can be carried out on baculovirus.
【作者单位】：河南农业大学生命科学学院;
【基金】：国家自然科学基金项目(31570151,31272094) 河南省高等学校重点科研项目(15A210039)
【分类号】：S476.13

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