用序列文本动态参照协助生物分子3D结构观察

发布时间：2018-04-28 21:37

本文选题：生物分子 + D可视化　；参考：《华中科技大学学报(自然科学版)》2017年04期

【摘要】：为了克服Jmol等传统工具在序列信息参照方式方面存在的缺陷,提出并实现了一种利用序列文本动态参照协助生物分子3D结构观察的方法.该方法利用Javascript,Frame,DIV,CSS,PHP和MySQL等Web相关技术,在Jmol基础上进行功能拓展.首先,分子序列文本与3D结构同时显示,且随着各种针对局部片段的操作同步发生变化.通过对序列文本特定编排以方便对局部片段的查看和定位,且利用下划线、删除线、上划线等多种文本样式及其配色来直观地表示多种局部操作结果状态.此外,还提供了多个序列片段的集中显示、历史操作状态的切换、当前状态的服务器保存等辅助功能.该方法在实际应用中取得了较好效果,有助于提升生物分子序列和结构相关生物信息的整合、模拟和可视化水平.
[Abstract]:In order to overcome the defects of traditional tools such as Jmol in the reference mode of sequence information, a method of using dynamic reference of sequence text to assist in 3D structure observation of biomolecules is proposed and implemented. In this method, the functions of Jmol are extended based on the Web related techniques, such as Web and MySQL. First, the molecular sequence text is displayed simultaneously with 3D structure, and changes synchronously with various operations for local fragments. By arranging the sequence text specifically to facilitate the viewing and locating of local segments, and by using a variety of text styles, such as underline, delete line, line on the line, and their color matching, we can intuitively express the state of various local operation results. In addition, some auxiliary functions are provided, such as the centralized display of multiple sequence fragments, the switching of the historical operation state, the server saving of the current state, and so on. The method has achieved good results in practical application and is helpful to improve the level of integration, simulation and visualization of biomolecules and structure-related biological information.
【作者单位】：华中科技大学生命科学与技术学院;华中科技大学教育部分子生物物理重点实验室;华中科技大学科技部基因工程国际合作基地;中南民族大学电子信息工程学院;
【基金】：国家自然科学基金资助项目(81373379) 科技部国际科技合作重点资助项目(2009DFB30340) 国家科技重大专项资助项目(2016ZX08010004-004) 湖北省自然科学基金资助项目(2012FFB07402) 中南民族大学中央高校基本科研业务费专项资金资助项目(CZY12004)
【分类号】：TP391.41

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