基于关联规则高血压病用药规律的研究

发布时间：2018-06-26 12:06

本文选题：高血压病 + 关联规则　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:运用关联规则方法挖掘中医治疗高血压病方剂,探讨高血压用药配伍规律,为临床高血压病治疗提供参考。方法:搜集整理2003年-2015年符合纳入标准的文献中治疗高血压病的中医内服方剂,建立相关数据集,运用SPSS Clementine12.0软件对方剂中药物进行挖掘分析,用Apriori算法建立相关数据挖掘模型,设置挖掘最大前项数为5,最小支持度及最小置信度分别为10%、90%,并运用Web节点将药物间的配伍组合进行图形化展示。结果:共获得符合标准的治疗高血压病内服方剂780首,共使用229种药物,总频次为7923次。使用频次在50以上的药物有46味,共使用6298次,占总频次的79.49%。在所有药物中补虚药的使用频次最高,共计1790次,占各类药物总使用频次的22.59%,其后依次为:平肝息风药、活血化瘀药、清热药、利水渗湿药、解表药、安神药、化痰药、祛风湿药、理气药。通过关联规则分析共获得符合条件的规则101条,其中四味药组合的规则最多,共产生47条;其次为三味药组合的规则,共获得37条。在所产生的规则中,包含天麻的规则最多,高达67条,其中前项中含天麻的规则有36条,后项中含有天麻的规则有31条。结论:天麻、钩藤、牛膝是高血压病的治疗要药;补虚药、平肝息风药在高血压病的治疗中占有重要地位;通过关联规则分析发现,平肝息风药、补虚药、活血化瘀药、清热药之间的配伍在高血压病的治疗中具有广泛应用,安神药在高血压病的治疗中具有重要的配伍意义。
[Abstract]:Objective: to explore the prescription of traditional Chinese medicine (TCM) for the treatment of hypertension by association rules, and to provide reference for clinical treatment of hypertension. Methods: collected and sorted the TCM prescriptions for hypertension treatment in the literature from 2003 to 2015, established the relevant data set, used SPSs Clementine 12.0 software to mine and analyzed the drugs in the prescriptions, and established the relevant data mining model by Apriori algorithm. The maximum number of items in mining is 5, the minimum support and confidence are 10 / 90 respectively, and the compatibility between drugs is displayed graphically by Web nodes. Results: a total of 780 prescriptions for the treatment of hypertension were obtained, and the total frequency was 7923 times. There were 46 kinds of drugs which were used more than 50 times, 6298 times, which accounted for 79.49 times of the total frequency. Among all the drugs, the use frequency of tonifying and deficiency drugs was the highest, 1790 times, accounting for 22.59 times of the total use frequency of all kinds of drugs, followed by: calming the liver and relieving wind, promoting blood circulation, removing blood stasis, clearing away heat, promoting water and infiltrating dampness, antitabular medicine, tranquilizing medicine, resolving phlegm medicine, Dispelling rheumatism medicine, regulating qi medicine. A total of 101 rules were obtained by association rule analysis, among which the combination of four kinds of drugs was the most common, with 47 rules, followed by the rule of combination of three kinds of drugs, with a total of 37 rules. Among the rules produced, there are as many as 67 rules including Gastrodia elata, among which 36 rules contain Gastrodia elata in the preceding item and 31 rules contain Gastrodia elata in the latter item. Conclusion: Gastrodia elata, hookwood and Achyranthes bidentata are the important drugs for the treatment of hypertension; the drugs for tonifying deficiency and soothing the liver and relieving wind play an important role in the treatment of hypertension; through the analysis of association rules, it is found that the drugs for calming the liver and relieving the wind, tonifying the qi, promoting blood circulation and removing stasis, The compatibility between antipyretic and antipyretic drugs is widely used in the treatment of hypertension.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259;TP311.13

【参考文献】