中医药调控脑缺血损伤血脑屏障通透性作用机制的研究进展

发布时间：2018-04-24 12:36

本文选题：脑缺血损伤 + 血脑屏障　；参考：《辽宁中医杂志》2013年10期

【摘要】：目的:对近年来关于中医药调控脑缺血损伤后血脑屏障通透性的作用机制作一整理,以期为中医药治疗脑缺血损伤提供参考。方法:以血脑屏障、脑缺血为关键词,通过中国知网及相关搜索引擎检索近20年的有关中医药调控血脑屏障及其机理方面的文章263篇,以中医药为关键词对文章进行了筛选,获得相关文献66篇。结果:阅读了66篇有关中医药与血脑屏障的文章,引用了37篇文章,发现中医药可通过多种机制对血脑屏障通透性有双向调控作用。结论:目前已经有很多研究从影响血脑屏障通透性因素方面证实了中医药可以双向调控血脑屏障通透性,肯定了中医药可以通过调控血脑屏障对脑缺血损伤其治疗作用,其中以芳香开窍类中药对血脑屏障通透性的影响研究为多。
[Abstract]:Aim: to study the mechanism of regulating blood-brain barrier permeability after cerebral ischemia injury by traditional Chinese medicine (TCM) in recent years in order to provide reference for the treatment of cerebral ischemia injury with Chinese medicine. Methods: blood brain barrier (BBB) and cerebral ischemia (BBI) were used as keywords. 263 articles on the regulation of BBB and its mechanism by Chinese medicine and related search engines were searched in the past 20 years, and the articles were screened with TCM as the key word. 66 papers were obtained. Results: 66 articles about traditional Chinese medicine and blood-brain barrier were read and 37 articles were cited. It was found that Chinese medicine can regulate the permeability of blood-brain barrier through various mechanisms. Conclusion: at present, many studies have proved that Chinese medicine can regulate the permeability of blood-brain barrier in both directions from the aspects of influencing the permeability of blood-brain barrier, and confirmed the therapeutic effect of Chinese medicine on cerebral ischemia injury by regulating blood-brain barrier. The effect of aromatic resuscitation Chinese medicine on blood-brain barrier permeability was studied.
【作者单位】：宁波医科大学研究生学院;宁夏医科大学中医学院;
【基金】：国家自然科学基金(81260569) 宁夏科技支撑计划(NXIC2012012)
【分类号】：R277.7

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