白细胞介素1β与癫痫发作相关性的Meta分析

发布时间：2019-06-05 22:19

【摘要】：目的系统评价白细胞介素1β(IL-1β)与癫痫发作的相关性。方法 2012年5月-2013年10月检索PubMed数据库(1985年1月-2013年7月)、Medline数据库(1985年1月-2013年7月)、中国知网(1998年1月-2013年7月)和万方数据库(1996年1月-2013年7月),并辅以谷歌学术搜索引擎进行手工检索。由两名研究者按照研究的纳入与排除标准进行病例对照研究的选择,对入选文献的质量参照"非随机对照临床试验质量评价标准与计分表"进行评价和计分,评估纳入研究的方法学质量并对有效的信息进行数据提取。然后采用RevMan5.0统计软件进行Meta分析,以加权均数差(WMD)为效应指标。结果共纳入5个研究,包括82例癫痫发作的患者和471例正常对照。所纳入的研究未描述详细的抽样方法及其检测方法的特异性。Meta分析结果显示:癫痫发作72 h以内的患者与正常对照人群之间血浆IL-1β的浓度差异无统计学意义[WMD=0.04 pg/mL,95%CI(-0.07,0.16)pg/mL,P=0.46]。结论 IL-1β可能没有直接参与癫痫的发作,而是通过与其他炎性因子之间的相互作用来实现。因此,需要进一步的研究来证明IL-1β在癫痫发作中的作用。
[Abstract]:Objective to systematically evaluate the correlation between IL-1 尾 (IL-1 尾) and epileptic seizures. Methods the PubMed database was searched from May 2012 to October 2013 (), Medline database from January 1985 to July 2013 (January 1985-July 2013). China knowledge Network (January 1998-July 2013) and Wanfang Database (January 1996-July 2013), supplemented by manual retrieval by Google academic search engine. A case-control study was conducted by two researchers according to the inclusion and exclusion criteria of the study, and the quality of the selected literature was evaluated and scored with reference to the "quality Evaluation criteria and scoring Table of non-randomized controlled Clinical Trials". Evaluate the methodological quality of the study and extract effective information. Then the Meta analysis is carried out by RevMan5.0 statistical software, and the weighted mean difference (WMD) is used as the effect index. Results A total of 5 studies were included, including 82 patients with seizures and 471 normal controls. The included study did not describe the detailed sampling methods and the specificity of their detection methods. Meta-analysis showed that there was no statistical significance in the difference of plasma IL-1 尾 concentrations between patients with seizures within 72 hours and normal controls. Meaning [WMD=0.04 pg/mL,] 95%CI (- 0.07, 0.16) pg/mL,P=0.46]. Conclusion IL-1 尾 may not be directly involved in epileptic seizures, but through interaction with other inflammatory factors. Therefore, further research is needed to prove the role of IL-1 尾 in seizures.
【作者单位】：梅州市人民医院癫痫专科;
【分类号】：R742.1

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