糖尿病患者遗忘型轻度认知功能损害的脑电信号分析

发布时间：2018-03-05 20:26

本文选题：糖尿病　切入点：认知功能损害　出处：《燕山大学》2014年博士论文　论文类型：学位论文

【摘要】：糖尿病发病率及导致的认知功能损害并发症逐年升高，严重影响患者的生活质量，给个人、家庭和社会造成沉重的精神和经济负担。糖尿病是导致老年人认知功能下降和痴呆的一个重要风险因素，糖尿病和衰老机制之间的复杂关系有待进一步揭示。从20世纪80年代开始，人们开始关注2型糖尿病与痴呆的关系，但至今问题没有得到解决。脑电是理解大脑的窗户，因此应用脑电信号研究糖尿病患者认识功能的损害机制以及经过康复治疗后对糖尿病患者进行跟踪，从而加深对糖尿病诱发的认知功能损害机制及其改善情况的认识和理解，对指导糖尿病患者认知功能损害的康复治疗具有重要意义。本论文致力研究遗忘型轻度认知功能损害2型糖尿病患者的脑电信号及事件相关脑电信号变化，主要进行了以下研究工作：首先，基于线性脑电信号分析，应用功率谱及一致性方法研究了遗忘型认知功能损害糖尿病患者各频段各脑区静息状态下脑电活动以及脑区内及脑区间的同步性，分析了EEG线性指标与神经心理量表得分之间的相关性。探讨了静息态脑电信号指标在认知功能评估中的作用，提出了糖尿病患者认知功能损害会表现出脑功能活动降低、同步性减弱，脑电信号分析更具客观性。其次，，基于非线性脑电信号分析，研究了排序熵和加权排序熵值在遗忘型认知功能损害糖尿病患者与正常对照组各个脑区的差异，以及二者随参数变化的敏感性。介绍了熵值指标与神经心理量表之间的相关性。提出了加权排序熵对噪声具有更强的鲁棒性，其在区分两组糖尿病患者中具有很好的实用价值。然后，基于事件相关EEG信号，提取了ERPs和离散小波一致性特征。将时间、脑区、频段和实验范式等信息相结合进行0.1到0.9之间数据归一化，应用基于互信息的最大相关最小冗余分析，对以上特征提取典型变量，对两组患者进行分类。提出了n-back范式对γ频段的影响更具显著性，与遗忘型轻度认知功能损害糖尿病患者工作记忆能力下降相关。指出Kanizsa虚幻图刺激在区分两组患者方面的研究仍有待进一步进行。最后，应用功率谱和全局同步索引方法分析了普拉提训练过程中健康大学生脑电信号，发现了普拉提训练使大脑神经网络变得更活跃，前额区和颞区的同步强度降低。本章为普拉提对脑功能干预的初步探讨，这为普拉提应用于大脑退化性疾病和认知功能障碍康复的干预提供了初步依据。
[Abstract]:The incidence of diabetes and the complications of cognitive impairment are increasing year by year, which seriously affects the quality of life of the patients and gives them to individuals. Family and society have a heavy mental and economic burden. Diabetes is an important risk factor for cognitive impairment and dementia in older people. The complex relationship between diabetes and aging needs to be further revealed. Since 1980s, attention has been focused on the relationship between type 2 diabetes and dementia, but the problem remains unresolved. EEG is the window to understanding the brain. Therefore, EEG is used to study the mechanism of cognitive impairment in diabetic patients and to follow up the diabetic patients after rehabilitation, so as to deepen the understanding and understanding of the mechanism of diabetes induced cognitive impairment and its improvement. This paper is devoted to study the changes of EEG and event-related EEG in patients with amnesia mild cognitive impairment type 2 diabetes mellitus. The following studies were carried out:. Firstly, based on the linear EEG analysis, the power spectrum and consistency methods were used to study the EEG activity and the synchronism of the brain regions and regions in the patients with amnesia cognitive impairment. The correlation between EEG linear index and the scores of neuropsychological scale was analyzed. The role of resting EEG in cognitive function evaluation was discussed. It was suggested that cognitive impairment of diabetic patients would result in decreased brain function activity. Synchronization is weakened and EEG analysis is more objective. Secondly, based on the analysis of nonlinear EEG signals, the difference of order entropy and weighted ordering entropy in different brain regions of patients with amnesia cognitive impairment diabetes mellitus and normal control group was studied. The correlation between the entropy index and the neuropsychological scale is introduced. The weighted ranking entropy is more robust to the noise, which has a good practical value in differentiating the two groups of diabetic patients. Then, based on the event-related EEG signal, the consistency features of ERPs and discrete wavelet are extracted, and the information of time, brain region, frequency band and experimental paradigm are combined to normalize the data between 0.1 and 0.9. Using the maximum correlation minimum redundancy analysis based on mutual information to extract the typical variables from the above features and classify the two groups of patients, it is proposed that the n-back normal form has a more significant effect on the 纬 band. It is pointed out that the study of Kanizsa illusory stimulation in differentiating the two groups needs to be carried out further. Finally, using power spectrum and global synchronous index method to analyze the EEG of healthy college students during Pilates training, it is found that Pilates training makes the neural network more active. This chapter is a preliminary study on the intervention of Pilates on brain function, which provides a preliminary basis for the intervention of Pilates in the rehabilitation of brain degenerative diseases and cognitive dysfunction.
【学位授予单位】：燕山大学
【学位级别】：博士
【学位授予年份】：2014
【分类号】：R587.1;TN911.6

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