大鼠脑缺血不同时期躯体感觉诱发电位的研究
发布时间：2018-08-03 19:53
【摘要】：脑电信号(EEG)具有较高的时间分辨率、可观测脑内活动的动态变化、完全无损检测等优点,常用于对神经系统疾病的诊断,本研究探讨脑缺血后躯体感觉诱发电位(SEP)变化及大脑皮层的功能恢复。利用线栓法建模成功的25只SD雄性大鼠分为5组,分别为正常对照组和左侧中动脉缺血术后4、24、48 h和1周4个实验组。采用SEP记录法,在术后不同时间段电刺激大鼠的右前爪正中神经支配区,记录对照组和实验组左侧皮层脑电信号,提取SEP,并对安静状态下的脑电进行频谱分析,定量评价左侧中动脉缺血后初级体感皮层SEP及功率谱变化过程。实验结果显示,术后4 h,SD大鼠左侧大脑皮层测得的SEP潜伏期较正常状态显著增大((16.0±1.1)ms vs(33.7±1.3)ms,P0.01),波幅变小((197.2±13.0)μV vs(25.1±2.0)μV,P0.01),θ波、α波、β波、γ波的能量明显变小。θ波:(139 367.86±178.66)μV2vs(2.22±0.40)μV2,P0.01;α波:(5389.33±25.55)μV2vs(0.23±0.01)μV2,P0.01;β波:(79.11±4.16)μV2vs(0.01±0.01)μV2,P0.01;γ波:(0.30±0.12)μV2vs(0.00±0.00)μV2,P0.01。随着术后时间的延长,上述特征与对照组的差距逐渐缩小,但还不能达到正常状态的水平。研究提示,SEP可在一定程度上反映脑缺血大鼠大脑皮层功能的变化。
[Abstract]:EEG (EEG) has the advantages of high time resolution, dynamic changes of brain activity, complete nondestructive detection and so on. It is often used in the diagnosis of nervous system diseases. The purpose of this study was to investigate the changes of somatosensory evoked potential (SEP) and cortical function after cerebral ischemia. A total of 25 SD male rats were divided into 5 groups: normal control group and 4 experimental groups at 48 h and 1 week after left middle artery ischemia. The right forepaw median nerve innervation was stimulated at different times after operation by SEP recording method. The left cortex EEG signals of the control group and the experimental group were recorded, and the electroencephalogram (EEG) was extracted from the left cortex of the control group and the experimental group. The electroencephalogram (EEG) in the quiet state was analyzed by spectrum analysis. The changes of SEP and power spectrum in primary somatosensory cortex after left middle artery ischemia were quantitatively evaluated. 瀹為獙缁撴灉鏄剧ず,鏈悗4 h,SD澶ч紶宸︿晶澶ц剳鐨眰娴嬪緱鐨凷EP娼滀紡鏈熻緝姝ｅ父鐘舵，
本文编号：2162835
[Abstract]:EEG (EEG) has the advantages of high time resolution, dynamic changes of brain activity, complete nondestructive detection and so on. It is often used in the diagnosis of nervous system diseases. The purpose of this study was to investigate the changes of somatosensory evoked potential (SEP) and cortical function after cerebral ischemia. A total of 25 SD male rats were divided into 5 groups: normal control group and 4 experimental groups at 48 h and 1 week after left middle artery ischemia. The right forepaw median nerve innervation was stimulated at different times after operation by SEP recording method. The left cortex EEG signals of the control group and the experimental group were recorded, and the electroencephalogram (EEG) was extracted from the left cortex of the control group and the experimental group. The electroencephalogram (EEG) in the quiet state was analyzed by spectrum analysis. The changes of SEP and power spectrum in primary somatosensory cortex after left middle artery ischemia were quantitatively evaluated. 瀹為獙缁撴灉鏄剧ず,鏈悗4 h,SD澶ч紶宸︿晶澶ц剳鐨眰娴嬪緱鐨凷EP娼滀紡鏈熻緝姝ｅ父鐘舵，
本文编号：2162835
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