水凝胶支架的飞秒激光全息加工

发布时间：2018-01-01 18:25

本文关键词：水凝胶支架的飞秒激光全息加工　出处：《光学精密工程》2017年09期 　论文类型：期刊论文

【摘要】：为了实现以水凝胶为材料的细胞支架快速加工,将计算全息法引入传统的飞秒激光双光子加工中,并对全息图的生成方法和全息图对加工结构的影响进行了研究。首先,根据贝塞尔光波动方程和其透射函数生成贝塞尔光束全息图,分析两种参数对环形结构大小和质量的影响。然后利用生成的全息图加工得到壁厚800nm、直径为8~15μm不等的水凝胶(PEGDA)圆管结构。最后,实现了基于圆管道的水凝胶细胞支架高效快速加工,支架中圆管道壁厚800nm、直径为8μm。本文首次将飞秒激光全息加工技术应用于水凝胶三维支架加工,解决了飞秒激光单点加工效率的问题。该技术在生物医学中具有广阔的应用前景。
[Abstract]:In order to realize the rapid fabrication of cell scaffolds based on hydrogel, the CGH method was introduced into the traditional femtosecond laser two-photon processing. The generation method of the hologram and the influence of the hologram on the fabrication structure are studied. Firstly, the Bessel beam hologram is generated according to the Bessel wave equation and its transmission function. The influence of two parameters on the size and mass of annular structure is analyzed, and then the wall thickness of 800 nm is obtained by using the generated hologram. The hydrogel cell scaffold with a diameter of 8 ~ 15 渭 m was fabricated quickly and efficiently, and the wall thickness of the circular tube was 800 nm. The diameter is 8 渭 m. In this paper, femtosecond laser holography is first applied to hydrogel three-dimensional scaffold processing. The problem of single point processing efficiency of femtosecond laser is solved and the technology has a broad application prospect in biomedicine.
【作者单位】：中国科学技术大学精密机械与精密仪器系;
【基金】：国家自然科学基金资助项目(No.51675503,No.61475149,No.51405464,No.61675190,No.51605463) 中央高校基本研究经费资助项目(No.WK2480000002) 中国博士后科学基金资助项目(No.2016M590578,No.2016M602027) 中科院仪器研制项目(No.YZ201566)
【分类号】：TN249
【正文快照】： 1引言水凝胶是一种高含水量的三维网状聚合物,是最有潜力替代生体软组织的生物材料,已广泛应用于组织工程等领域[1]。三维细胞支架结构决定培育细胞后组织的形貌特点和细胞的生长情况,因此通过构建可控的三维细胞支架来灵敏地控制细胞的增殖行为[2]和迁移行为[3],在组织工程研

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