固体核磁共振技术在骨基生物材料研究中的应用

发布时间：2018-02-19 23:21

本文关键词： 固体核磁共振(solid-state NMR) 骨头羟基磷灰石生物玻璃生物矿化　出处：《波谱学杂志》2017年01期 　论文类型：期刊论文

【摘要】：骨是人体的结构组织之一,又是重要的造血器官,它在支持和保护体内器官、贮存钙和磷、参与人体代谢和为肌肉提供附着等方面具有重要的作用,因此了解骨的微观结构对预防和治疗骨疾病有重要意义.由于骨形态多样化,无机和有机成分共存,而且骨样品对物理和化学处理十分敏感,因此对其研究存在许多实验困难.与其他表征技术相比,固体核磁共振(NMR)检测对骨样品不需要任何处理,不会破坏其自身结构,可以实现原位检测.另外,骨头中的许多元素(~1H、~(13)C、~(31)P、~(19)F、~(43)Ca、~(29)Si、~(25)Mg和~(87)Sr)都是NMR可观察核,因此高分辨固体NMR技术是研究骨基生物材料的强有力工具,该文综述了近年来固体NMR技术在骨基生物材料研究中的应用进展.
[Abstract]:Bone is one of the structural tissues of human body and an important hematopoietic organ. It plays an important role in supporting and protecting internal organs, storing calcium and phosphorus, participating in human metabolism and providing attachment to muscles. Therefore, understanding the microstructure of bone is of great significance for the prevention and treatment of bone diseases. Because of the diversity of bone morphology, the coexistence of inorganic and organic components, and the sensitivity of bone samples to physical and chemical treatment, Compared with other characterization techniques, solid state magnetic resonance imaging (SNMR) does not require any treatment of bone samples, does not destroy its own structure, and can be used for in situ detection. Many of the elements in bone are NMR observable nuclei. Therefore, high resolution solid state NMR is a powerful tool for studying bone based biomaterials. This paper reviews the recent advances in the application of solid NMR technology in the study of bone based biomaterials.
【作者单位】：中国科学院强磁场科学中心;
【基金】：国家自然科学基金资助项目(21203202)
【分类号】：O482.532

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