全自动多通道高精度分液系统设计与实现

发布时间：2018-01-29 10:13

本文关键词： 全自动高精度分液系统 SoC　出处：《重庆大学》2016年硕士论文　论文类型：学位论文

【摘要】：分液系统被广泛应用于饮料分装、食品生产、临床医疗、生化实验、药物研发等领域,尤其是在临床医疗领域,需要采用高精度、无污染的微量分液设备进行分液操作,以保证后续检测结果的准确性。我国微量分液系统产品较少,仪器的分液精度普遍不高、稳定性较差;目前市场中主流的高精度分装系统大多由国外企业制造生产,其价格昂贵、体积较大。因此,自主研发一款小型化、低成本的微量高效分液系统,具有较高的社会价值和经济效益。论文选用ARM+FPGA的SoC架构,设计了一款全自动、高精度、无污染、多控制端的微量液体分装系统。通过设计泵阀一体模块,有效地提高了仪器的分液精度、降低了仪器的成本;通过设计电容式液面探测模块,极大地减少了仪器在分液过程中出现的液体漏加、液体间交叉污染以及分液针挂液等现象,进一步提高了仪器的分液精度;搭建SoC系统,通过在FPGA资源中设计相应的控制逻辑,实现对电机、传感器等外设的驱动控制;通过在HPS中移植Linux操作系统、Qt图形界面开发库以及SQLite轻量级数据库,实现仪器主控软件设计;通过开发手机控制软件对仪器进行远程控制和信息管理,在对有毒有害液体的分液环境中,有效地保障了操作人员的人身安全。论文的主要贡献有:(1)根据泵阀一体的实现原理,提出了分段补偿的方法,消除了因电机丢步和空气压缩带来的分液误差,提高了分液精度;(2)针对分液过程中存在交叉污染的问题,采用电容式传感器作为信号来源,利用电容—占空比转换方式实现了对液面的精准探测;(3)针对有毒、有害液体进行分液时可能存在威胁操作员人身安全的问题,采用先进的多终端控制方式,实现了对仪器的灵活控制。论文实现了微量高效的分液系统设计,该系统包括仪器分液、洗涤、保养、多终端控制等多项功能,控制软件结构清晰、界面友好。经反复测试验证,系统可达到450孔位/小时的分液速度、5ul的分液量级、99.6%的液面探测准确度。达到了合作公司提出的要求。
[Abstract]:Liquid separation system is widely used in beverage packaging, food production, clinical medicine, biochemical experiments, drug development and other fields, especially in the field of clinical medicine, need to use high accuracy. In order to ensure the accuracy of the follow-up detection results, there are few products of the micro-liquid separation system in China, the accuracy of the instrument is generally low, and the stability of the instrument is poor. At present, most of the mainstream high-precision fractionation systems in the market are manufactured by foreign enterprises, which are expensive and large in volume. Therefore, a miniaturized and low-cost micro-high efficient liquid separation system has been developed independently. It has high social value and economic benefit. In this paper, ARM FPGA SoC framework is used to design a fully automatic, high-precision and pollution-free model. By designing the integral module of pump valve, the precision of liquid separation of the instrument is improved effectively, and the cost of the instrument is reduced. Through the design of capacitive liquid level detection module, the leakage of liquid, cross-contamination between liquids and the suspension of liquid needle in the separation process of the instrument are greatly reduced, and the precision of liquid separation is further improved. The SoC system is built, and the corresponding control logic is designed in the FPGA resource to realize the drive control of the motor, sensor and other peripheral devices. The design of instrument master control software is realized by transplanting Linux operating system QT graphical interface development library and SQLite lightweight database in HPS. Through the development of mobile phone control software for remote control of the instrument and information management in the toxic and harmful liquid separation environment. The main contribution of this paper is: 1) according to the realization principle of pump valve, the method of piecewise compensation is put forward. The separation error caused by motor step loss and air compression is eliminated, and the separation accuracy is improved. (2) aiming at the problem of cross contamination in liquid separation process, capacitive sensor is used as signal source and precise detection of liquid surface is realized by means of capacitance-duty cycle conversion. 3) aiming at the problem that the poisonous and harmful liquid may threaten the personal safety of the operator, the advanced multi-terminal control method is adopted. The paper realizes the design of micro-high efficient liquid separation system, which includes the functions of instrument separation, washing, maintenance, multi-terminal control and so on, and the control software structure is clear. The interface is friendly. After repeated test and verification, the system can reach the level detection accuracy of 99.6% of 450pore / hour liquid separation speed of 5ul, which meets the requirements of the cooperation company.
【学位授予单位】：重庆大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：TH89

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