原子力显微镜在细胞力学特性研究中的进展

发布时间：2018-03-08 18:53

  本文选题：原子力显微镜(AFM)　切入点：细胞　出处：《微纳电子技术》2014年09期 　论文类型：期刊论文

【摘要】：原子力显微镜(AFM)能够以高分辨率和高灵敏度实现液体环境下活细胞的操作和检测,利用AFM力曲线测量功能还可以获得细胞力学特性的相关信息。在简要介绍AFM力曲线测量原理的基础上,从细胞的杨氏模量、硬度和配体-受体之间相互作用力三个方面,详细阐述了近年来AFM在细胞力学特性研究中的发展状况,并着重介绍了其在细胞杨氏模量研究中的进展,表明AFM已经成为细胞力学特性研究中重要的生物显微技术。最后,针对AFM的不足及局限性,提出了目前存在的问题,并对AFM在细胞力学特性研究中的前景进行了展望。
[Abstract]:Atomic Force microscope (AFM) enables the operation and detection of living cells in liquid environments with high resolution and sensitivity. On the basis of a brief introduction to the measurement principle of AFM force curve, the cell's Young's modulus, hardness and ligand-receptor interaction force can be obtained from three aspects: the Young's modulus of the cell, the hardness of the cell and the interaction between the ligand and the receptor, based on a brief introduction of the measurement principle of the AFM force curve. The development of AFM in the study of cellular mechanical properties in recent years was reviewed in detail, and its progress in the study of cell Young's modulus was emphasized. The results show that AFM has become an important biomicroscopic technique in the study of cellular mechanical properties. In view of the shortcomings and limitations of AFM, the existing problems are put forward, and the prospect of AFM in the study of cellular mechanical properties is prospected.
【作者单位】： 长春理工大学电子信息工程学院;吉林省纳米操纵装配与制造国际科技合作基地;贝德福特大学计算机控制纳米制造技术联合研究中心;
【基金】：国家国际科技合作计划资助项目(2012DFA11070) 欧盟第七研究框架计划资助项目(269219,318971) 吉林省科技计划资助项目(20100703,20102,201215136) 长春市科技计划资助项目(10GH15,11KP04)
【分类号】：TH742
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本文编号：1585139