POCT型全自动生化分析仪集成光电检测模组及系统软件的开发

发布时间：2018-07-02 20:07

本文选题：全自动生化分析仪 + POCT　；参考：《深圳大学》2015年硕士论文

【摘要】：基于自动生化分析技术的全自动生化分析仪是目前临床上应用最为广泛的一种体外诊断定量分析仪,通过对人体体液的检验,可对各项生化指标进行测定、分析,如免疫球蛋白、胆红素、血脂、血糖等。但目前市面上的全自动生化分析仪多为大型仪器、三级软件通信架构,且需配合PC机使用,体积大、操作繁琐。因此,本课题基于分光光度法测量原理,采用二级通信架构,开发一套POCT化、准确、稳定、并且适用于全自动生化分析仪的集成光电检测模组及系统软件。通过对全自动生化分析仪的测量原理分析,调研生化分析常用方法,提出集成光电检测模组与系统软件的设计需求,完成POCT型全自动生化分析仪的概要设计。根据设计需求完成基于Optical Engines的集成光电检测模组的硬件设计、多通道光信号采集模块设计、模组固定设计;并以Visual C++和ADS作为调试环境,按照系统软件的功能,完成人机交互模块软件设计、主控系统软件设计、下位机软件设计。研究后期,将本课题设计的集成光电检测模组与系统软件应用在第二方设计的全自动生化分析仪硬件系统,通过对集成光电检测模组的杂散光、吸光度稳定性、重复性,以及整机相关性能等指标进行实验测试,实验结果表明本课题设计的集成光电检测模组及系统软件的各有关性能指标满足《YY/T0654-2008中华人民共和国医药行业标准-全自动生化分析仪》,符合国家标准及设计需求。
[Abstract]:The automatic biochemical analyzer based on automatic biochemical analysis technology is one of the most widely used in vitro diagnostic quantitative analyzer in clinic at present. Through the examination of human body fluid, the biochemical indexes can be measured and analyzed. Such as immunoglobulin, bilirubin, blood lipid, blood sugar and so on. But at present, most of the automatic biochemical analyzer on the market are large-scale instruments, three-level software communication architecture, and need to be used with PC, large volume, cumbersome operation. Therefore, based on the principle of spectrophotometric measurement, a set of integrated optoelectronic detection modules and system software for automatic biochemical analyzer is developed by using a two-level communication structure, which is accurate, stable and suitable for automatic biochemistry analyzer. By analyzing the measuring principle of automatic biochemical analyzer and investigating the common methods of biochemical analysis, this paper puts forward the design requirements of integrated photoelectric detection module and system software, and completes the outline design of POCT automatic biochemical analyzer. According to the design requirements, the hardware design of the integrated photoelectric detection module based on optical engines, the design of the multi-channel optical signal acquisition module, the fixed module design, the debugging environment of Visual C and ads, and the function of the system software are completed. Complete the design of man-machine interaction module software, master control system software design, lower computer software design. In the later stage of the research, the integrated photoelectric detection module and the system software designed by this subject were applied to the hardware system of the automatic biochemical analyzer designed by the second party. Through the stray light, absorbance stability and repeatability of the integrated photoelectric detection module, As well as the related performance of the whole machine to carry on the experimental test, The experimental results show that the performance indexes of the integrated photoelectric detection module and the system software designed in this paper meet the < YY / T0654-2008 standard of the pharmaceutical industry of the people's Republic of China-automatic biochemistry analyzer, and meet the national standards and design requirements.
【学位授予单位】：深圳大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TH776

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