光纤分导微梁阵列生化传感装置研制及检测应用

发布时间：2018-01-09 22:04

  本文关键词：光纤分导微梁阵列生化传感装置研制及检测应用　出处：《分析化学》2017年01期 　论文类型：期刊论文

  更多相关文章： 生物化学传感器 光导纤维 悬臂梁阵列 汞离子 定量检测

【摘要】：研制了一套基于光杠杆原理的微悬臂梁阵列传感器平台,并通过使用设计制作的微悬臂梁阵列芯片展示其在生物化学方面的检测应用。传感器平台使用光导纤维束分别与激光器耦合作为悬臂梁阵列的扫描光源,具有良好的检测稳定性,检测信号噪声水平约为2 nm;设计制作的微悬臂梁阵列芯片具有良好的平直度,温度响应均匀一致,各梁温度改变响应灵敏度偏差不超过5.0%。将整套传感系统被用于检测水溶液中的Hg2+,检测浓度范围为1~200 ng/m L;同一浓度下微悬臂梁阵列检测结果曲线一致性良好,平均偏差小于15%。在研制仪器平台上,分别实现了自制和国外商品化芯片对1.0和0.2 ng/m L样品的检测,结果表明,制作的微悬臂梁阵列芯片的检测灵敏度相对较低,需进一步改进悬臂梁阵列制作工艺。
[Abstract]:A micro cantilever array sensor platform based on optical lever is developed. By using the designed microcantilever array chip to demonstrate its biochemistry detection application. The sensor platform uses the optical fiber bundle coupled with the laser as the scanning light source of the cantilever beam array. It has good detection stability, the noise level of the detection signal is about 2 nm; The designed microcantilever array chip has good flatness and uniform temperature response. The sensitivity deviation of each beam temperature change response is not more than 5.0. The whole sensing system is used to detect Hg2 in aqueous solution with a concentration range of 1 ~ 200 ng/m / L; The results of microcantilever array detection at the same concentration are consistent with each other, and the average deviation is less than 15. The detection of 1. 0 and 0. 2 ng/m / L samples by commercial chips made by ourselves and abroad has been realized respectively. The results show that the detection sensitivity of the fabricated microcantilever array chips is relatively low. The fabrication process of cantilever beam array should be further improved.
【作者单位】： 中国科学院材料力学行为和设计重点实验室中国科学技术大学近代力学系;美奥微系统有限公司;
【基金】：国家自然科学基金项目(Nos.11627803,11502265,11472266) 中国科学院战略性先导科技专项(B类)(No.XDB22040502)资助~~
【分类号】：TP212
【正文快照】： 本文系国家自然科学基金项目(Nos.11627803,11502265,11472266)及中国科学院战略性先导科技专项(B类)(No.XDB22040502)资助*E-mail:wushq@ustc.edu.cn;zhangqc@ustc.edu.cn1引言微悬臂梁传感技术是目前在生物化学检测领域具有广泛发展前景的传感技术手段。微悬臂梁传感器的设，

本文编号：1402685