基于零热流原理的脑部核心温度便携式监测设备研究

发布时间：2018-03-17 11:15

  本文选题：零热流方法　切入点：核心温度　出处：《合肥工业大学》2017年硕士论文　论文类型：学位论文

【摘要】：人体脑部核心温度重要的生理参数,在疾病监测、诊断和治疗中发挥重大的作用。对人体脑部核心温度的监测有利于疾病的早期发现、诊断和治疗方案的决定。由于脑部的封闭性和安全的重要性,常用的温度测量方法如直接接触、红外测温不适合用于核心温度长时间的连续检测。本文针对这一重要问题,基于零热流原理,使用价格低廉的MSP430单片机芯片和常见的PT100温度传感器设计并实现了一种核心温度的检测方案。本设计中传感器采用两组PT100热敏电阻和一个精确参考电阻,采取恒流源测温方法,通过仪表放大器AD620放大所需的温度变化信号,最终通过MSP430采用12位的模数转换器进行采集。在控制模块部分对采集的数据进行处理和分析,通过比例积分控制算法实现对加热模块的控制,实现零热流,最终获取人体脑部的核心温度。相对于传统测温设备,具有以下的优势:(1)采用零热流原理,提供了一种核心温度便携式监测手段,对国内核心温度研究方法的补充;(2)采用零热流方法,于前额部位采集脑部核心温度,非侵入式的无创的监测方法使得核心温度的检测容易被接受;(3)采用恒流源方法,电路结构简单,并保持了热敏电阻PT100在小温度范围(32-42℃)内的线性特性,有利于提高温度测量的精度;(4)采用电池供电,贯穿便携式的设计理念,相对于传统的监测设备灵活,使得核心温度检测可以随时随地进行;(5)设计采用MSP430F149芯片和常见的传感器,使得核心温度的检测成本大大降低;(6)设计的核心温度采集系统可以获取人体核心温度的变化节律,对于生物钟和慢性疾病的研究具有重要意义。为保证实验的可靠和准确,通过恒温水浴锅对温度传感器进行校准;并采用对照实验方法,同时使用耳温枪和所设计的传感器采集26名受试者的脑部核心温度。比较实验结果发现两者核心温度的测量结果无显著性差异。同时,使用耳温枪和零热流传感器连续采集受试者5天核心温度,观察核心温度的周期变化节律。测量结果表明耳温枪测量的核心温度范围为(37.06士 0.21)℃,零热流传感器所检测的核心温度的变化范围(37.17 ± 0.24)℃。二者温度测量结果变化趋势,经协方差分析发现,相关系数ρ= 0.92 0.8,具有高度的相关性和一致性。
[Abstract]:The important physiological parameters of the core temperature of the human brain play an important role in disease monitoring, diagnosis and treatment. Monitoring the core temperature of the human brain is conducive to the early detection of diseases. Because of the importance of brain closure and safety, common temperature measurement methods such as direct contact, infrared temperature measurement are not suitable for continuous detection of core temperature for a long time. Based on the principle of zero heat flux, a kind of core temperature detection scheme is designed and realized by using cheap MSP430 chip and common PT100 temperature sensor. In this design, two groups of PT100 thermistor and one accurate reference resistor are used in the design. The method of constant current source temperature measurement is adopted to amplify the required temperature change signal through the instrument amplifier AD620, and finally the 12 bits A / D converter is used to collect the data through MSP430. The collected data are processed and analyzed in the control module. The control of the heating module is realized by the proportional integral control algorithm, and the zero heat flux is realized. Finally, the core temperature of the human brain is obtained. Compared with the traditional temperature measuring equipment, it has the following advantages: 1) adopting the zero heat flux principle. A portable monitoring method for core temperature is provided. The core temperature in the brain is collected from the frontal area by using zero heat flux method, which is a supplement to the domestic core temperature research method. The noninvasive non-invasive monitoring method makes the core temperature detection easily accepted. (3) the constant current source method is adopted, the circuit structure is simple, and the linearity of the thermistor PT100 is maintained in the small temperature range of 32-42 鈩，

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