可植入式柔性眼压传感器及其测控技术研究

发布时间：2018-04-02 02:13

本文选题：青光眼　切入点：可植入式　出处：《南昌航空大学》2017年硕士论文

【摘要】：眼压信号是青光眼患者特别是重症青光眼患者需要实时、准确监测的一项非常重要的生理信号。目前医院常用的眼压测量仪器,由于其尺寸大,无法连续监测且需要外人协助测量等因素的影响,无法满足患者24小时眼压较为准确、方便地测量。为此,本文研究了一种可植入式柔性眼压传感器用于青光眼患者的眼压长时间连续监测,并且主要围绕眼压传感器的工作原理、结构设计、工艺制作、测控系统、表征和性能测试等方面进行研究。本文首先分析总结了国内外可植入式眼压传感器和柔性压力传感器的研究现状并提出了一种基于微纳接触敏感机制的电容式压力传感器。这种微纳接触敏感结构的电容式压力传感器受压力作用后,具有易变形、介电常数变化大的特点,因此能够提高传感器的灵敏度。根据传感器的原理、结构设计和可植入的特殊应用,本文选用了可生物兼容的材料,并且主要研究了两种微纳接触结构的电容式压力传感器的制作工艺。一种是利用规则的金字塔结构,另一种是利用多壁碳纳米管制作微纳接触结构。综合分析比较了两种方法的优缺点,并重点对多壁碳纳米管制作的微纳接触结构的电容式压力传感器进行研究。传感器的测控系统也是本文的重要研究内容,它主要由密封腔体、环境控制模块、信号处理模块组成。考虑到眼压的特殊环境,本文设计、制作的密封腔体和环境控制模块能够控制密封腔体内的压力、温度等环境因素。信号处理模块主要包括电容检测电路和电子测量仪器,用于检测和传输传感器的信号。此外,设计、制作的固态压力系统,用于传感器对固态压力的响应。建立的传感器测控系统能满足眼压传感器的性能测试和模拟体内眼压环境的要求。最后通过高精密测量仪器和传感器测控系统对传感器进行表征和性能测试。实验结果表明,本文研究的基于微纳接触敏感结构的电容式压力传感器具有良好的稳定性、重复性、迟滞,传感器的灵敏度可达1.3/kPa,传感器对微小压力的响应时间达到毫秒级,并且不易受温度的影响。这种高性能的可植入式柔性眼压传感器,经过合适的封装后,不仅适用于体内眼压的测量,而且也会有力地推进新型微传感器在医疗、健康监测、移动健康服务等领域的应用。
[Abstract]:The intraocular pressure signal is especially severe in patients with glaucoma glaucoma patients need real-time, a very important physiological signal monitoring accurately. At present the hospital commonly used intraocular pressure measuring instrument, because of its large size, not continuous monitoring and the influence factors such as the measurement need outside help, unable to meet the patient 24 hours intraocular pressure is more accurate, convenient for measurement. In this paper, an implantable flexible intraocular pressure sensor for glaucoma intraocular pressure long time continuous monitoring, and focuses on the working principle of the sensor, IOP structural design, fabrication, measurement and control system, studied the characterization and performance test. This article analyzes the domestic and foreign research status of implantable sensors and flexible intraocular pressure the pressure sensor and presents a capacitive pressure sensor based on micro nano touch sensitive mechanism. This kind of micro nano contact sensitivity The sense of capacitive pressure sensor structure under pressure, has the characteristics of large deformation, the variation of dielectric constant, so it can improve the sensitivity of the sensor. According to the sensor principle, structure design and special application of implantable materials can be selected, bio compatible, and mainly studies the production process of two kinds of capacitors the pressure sensor micro contact structure. One is the Pyramid structure with rules, another is the use of carbon nanotubes to make micro nano contact structure of multi wall. A comprehensive analysis and comparison of advantages and disadvantages of the two methods, and focus on the production of multi walled carbon nanotubes micro capacitive pressure sensor contact structure. Study. An important research content of measurement and control system is the sensor, which mainly comprises a sealing cavity, environment control module, signal processing module. Considering the special environment of the intraocular pressure, this paper design That made the seal chamber and the environment control module can control the sealing cavity pressure, environmental factors such as temperature. The signal processing module mainly includes the capacitance detection circuit and electronic measuring instrument, used for signal detection and transmission of the sensor. In addition, design, solid pressure production system, in response to pressure sensor on the solid-state sensor control. The establishment of the system can meet the performance test and Simulation of intraocular pressure sensor in intraocular pressure environment. Finally through the measurement and control system for high precision measuring instrument and sensor characterization and performance test of the sensor. The experimental results show that the hysteresis capacitive pressure sensor based on micro nano touch sensitive structure has good stability and repeatability. The sensitivity of the sensor can reach 1.3/kPa, the response time of the micro pressure sensor to milliseconds, and it is not affected by temperature. This high-performance implantable flexible intraocular pressure sensor is suitable for measuring intraocular pressure in vivo after proper encapsulation. It will also effectively promote the application of new microsensor in medical, health monitoring, mobile health services and other fields.

【学位授予单位】：南昌航空大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TP212

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