基于智能移动设备的非接触式生物传感器的研制

发布时间：2018-05-19 07:49

本文选题：非接触式技术 + 智能移动设备　；参考：《东南大学》2017年硕士论文

【摘要】：非接触式技术在生物传感器中具有广泛的应用,它与生物传感器的结合,避免了直接接触造成的二次污染,省去了更换相关装置的麻烦,降低了实验和观测的成本,增加了传感器应用场合的灵活性,使得24小时连续监测成为可能。但是目前的非接触式技术比较复杂,与之结合使用的电路单元或者仪器设备较为庞大,不便于随身携带,基于智能移动设备的非接触式技术与生物传感器结合,是医疗健康领域技术发展的一个重要方向。本文中,我们将智能手机与非接触式技术结合起来应用于生物传感器中,制备出更加智能化、小型化的生物传感器。研究工作的内容可分为以下三个部分:一、在传感器的信号检测环节,利用基于手机摄像头的光学检测,并应用在唾液淀粉酶检测中。设计了用于唾液淀粉酶检测的纸芯片并选择EPS速率法进行淀粉酶检测;开发了基于android手机的用于芯片比色检测的APP,选择合适的算法对目标区域进行识别和检测。制备出的芯片可以进行批量生产,且这种检测方法不受检测样品数量的限制。二、在传感器的能量供应环节,利用电磁感应无线充电技术为分析芯片供电,并应用于乳酸检测中。从提高无线传输效率的角度入手,设计了能量发射电路、接收电路及无线PCB线圈,制作出在传输距离5mm以内,输出电压在0.9～1.5V之间的无线充电系统;设计了基于电致变色的传感器阵列,调节电致变色材料普鲁士蓝中存储的电量控制乳酸的检测限;制备的乳酸检测芯片可以直接通过裸眼读取普鲁士蓝点阵变无色的个数进行半定量检测。三、在传感器的信号传输环节,利用无线WiFi技术进行离子浓度的检测,设计了可穿戴设备的雏形。利用柔性PCB板制作了离子检测传感器的数据采集和传输电路,利用手机WiFi接收传输的数据进行计算和显示,并传输至服务器进行存储。
[Abstract]:Non-contact technology is widely used in biosensors. The combination of non-contact technology and biosensor avoids the secondary pollution caused by direct contact, saves the trouble of replacing related devices, and reduces the cost of experiment and observation. The flexibility of sensor applications is increased, and 24-hour continuous monitoring is possible. However, the current non-contact technology is more complex, and the circuit unit or instrument equipment used with it is relatively large, which is not easy to carry around. The non-contact technology based on intelligent mobile device is combined with biosensor. It is an important direction of technical development in the field of medical and health. In this paper, we combine smart phone and contactless technology into biosensor to produce a more intelligent and miniaturized biosensor. The research work can be divided into the following three parts: first, in the sensor signal detection, using the camera based on mobile phone optical detection, and the application in saliva amylase detection. The paper chip for saliva amylase detection was designed and the EPS rate method was selected to detect the amylase. The app for chip colorimetric detection based on android mobile phone was developed and the appropriate algorithm was selected to identify and detect the target area. The chip can be produced in batch, and the detection method is not limited by the number of samples. Secondly, in the energy supply link of the sensor, the electromagnetic induction wireless charging technology is used to supply power for the analysis chip, and it is applied to the detection of lactic acid. In order to improve the wireless transmission efficiency, the energy transmitting circuit, the receiving circuit and the wireless PCB coil are designed, and the wireless charging system with output voltage between 0.9V and 1.5V is made within the transmission distance 5mm. A sensor array based on electrochromic method was designed to adjust the detection limit of lactic acid stored in the electrochromic material Prussian Blue. The prepared lactic acid detection chip can be used to detect the number of colorless Prussian blue dots directly through naked eyes. Thirdly, in the signal transmission link of sensor, using wireless WiFi technology to detect ion concentration, the prototype of wearable device is designed. The data acquisition and transmission circuit of ion detection sensor is made by using flexible PCB board. The data received and transmitted by mobile phone WiFi is calculated and displayed and transmitted to the server for storage.
【学位授予单位】：东南大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TP212.3

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