基于超表面（Metasurface）的太赫兹传感器及其在生物医学领域的应用研究

发布时间：2018-05-24 19:59

本文选题：超表面 + 太赫兹生物传感器　；参考：《桂林电子科技大学》2017年硕士论文

【摘要】：太赫兹波光子能量远小于X射线的能量,不会对人体产生电离辐射、安全性好,因此,太赫兹技术在生物医学领域的应用研究成为当前的一个研究热点。由于生物组织含水,水对太赫兹波的吸收很强烈,导致太赫兹波衰减十分严重,这成为太赫兹技术在生物医学领域应用的一大障碍。人工电磁材料(超材料)的出现,特别是超表面的发展,对太赫兹技术在生物医学领域的应用起到了极大的促进作用。因为超表面制作的高灵敏度太赫兹传感器,对表面介电环境的变化十分敏感,可利用这一特性来表征和监测药物反应的特征变化。本文主要开展超表面太赫兹传感器的太赫兹响应特性及其在生物医学领域的应用研究,具体研究内容如下:1.研究超表面太赫兹传感器的理论、设计方法、加工方法和传感特性。设计了欧姆环结构、开口环与一字形复合结构两种超表面太赫兹传感器,并用表面微加工工艺制作出了样片。2.研究超表面太赫兹传感器用于蛋白质与药物反应过程监测。首先,选取罗红霉素、头孢拉定、诺氟沙星和环丙沙星四种药物溶液与牛血清白蛋白溶液进行反应,然后取微量反应溶液滴到传感器表面,用太赫兹时域光谱系统测定反应溶液在不同时间的太赫兹时域透射光谱,根据传感器谐振峰的频移变化来表征反应过程。研究表明,超表面太赫兹传感器可用于监测蛋白质与药物的反应过程,为后续其它蛋白质与药物反应的研究提供了一种新型、高效的方法。3.研究超表面太赫兹传感器对不同抗生素类药物浓度的检测。选取环丙沙星、罗红霉素和诺氟沙星这三种常见抗生素进行实验,实验发现开口环与一字形复合结构的谐振峰频移量与抗生素浓度大小近似成正比例关系。而且,开口环与一字形复合结构对不同抗生素浓度的敏感程度不完全一样。因此,超表面太赫兹传感器可以实现对不同抗生素类药物浓度的检测。4.研究将超表面太赫兹生物传感器用于抗癌药与核酸反应过程监测。通过对秋水仙碱和甲氨蝶呤两种抗癌药与核酸的反应过程进行研究,证明了超表面太赫兹传感器用于抗癌药与核酸反应过程监测的可行性。这些研究成果,对处于攻关阶段的抗癌药及其药效研究具有十分重要的意义。
[Abstract]:The energy of terahertz photons is much smaller than that of X-ray, and it will not produce ionizing radiation to human body. Therefore, the application of terahertz technology in biomedical field has become a hot research topic. Because of the water content in biological tissues, the absorption of terahertz wave by water is very strong, resulting in the attenuation of terahertz wave is very serious, which has become a major obstacle to the application of terahertz technology in biomedical field. The appearance of artificial electromagnetic materials (metamaterials), especially the development of supersurface, has greatly promoted the application of terahertz technology in biomedical field. The high sensitivity terahertz sensor is very sensitive to the change of the dielectric environment of the surface, which can be used to characterize and monitor the characteristic changes of the drug reaction. In this paper, the terahertz response of supersurface terahertz sensor and its application in biomedical field are studied. The research contents are as follows: 1. The theory, design method, processing method and sensing characteristics of supersurface terahertz sensor are studied. Two kinds of super-surface terahertz sensors were designed with ohmic ring structure, open ring and one zigzag composite structure. The supersurface terahertz sensor is used to monitor the reaction between protein and drugs. Firstly, roxithromycin, cefradine, norfloxacin and ciprofloxacin were selected to react with bovine serum albumin solution. Terahertz time-domain spectroscopy system was used to measure the THz time-domain transmission spectra of the reaction solution at different times. The reaction process was characterized by the frequency shift of the resonant peak of the sensor. The results show that the surface-THz sensor can be used to monitor the reaction process between protein and drug, which provides a new and efficient method for the further study of the reaction between other proteins and drugs. The determination of concentration of different antibiotics by surfaced terahertz sensor was studied. Three common antibiotics, ciprofloxacin, roxithromycin and norfloxacin, were selected for experiments. It was found that the resonant peak frequency shift of the open ring and a zigzag composite structure was approximately proportional to the concentration of antibiotics. Moreover, the sensitivity of the open ring and a zigzag composite structure to different antibiotic concentrations is not exactly the same. Therefore, the supersurface terahertz sensor can be used to detect the concentration of different antibiotics. The supersurface terahertz biosensor was used to monitor the reaction of anticancer drugs with nucleic acid. By studying the reaction process of colchicine and methotrexate with nucleic acid, it is proved that the supersurface terahertz sensor can be used to monitor the reaction process between anticancer drug and nucleic acid. These results are of great significance to the study of anticancer drugs and their efficacy at the critical stage.
【学位授予单位】：桂林电子科技大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TP212

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