EVALUATION ON SAFETY AND EFFECTIVENESS ABOUT INSULIN GLARGIN

  本文关键词：地特胰岛素注射液的临床效果和经济学评价研究综述，由笔耕文化传播整理发布。

《Journal of Hebei Medical University》 2014-04

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EVALUATION ON SAFETY AND EFFECTIVENESS ABOUT INSULIN GLARGINE INJECTION AT DIFFERENT TIME IN PATIENTS WITH TYPE 1 DIABETES MELLITUS

YU Lihong;LI Chunhui;SU Shengou;ZHOU Hong;Department of Endocrinology,the Second Hospital of Hebei Medical University;  

Objective To evaluate the safety and the effectiveness about subcutaneous injection of insulin glargine at different time in patients with type 1 diabetes mellitus.Methods Clinical data about 36 inpatients with type 1 diabetes from our hospital were collected.Twelve patients were treated with insulin glargine combined with biosynthetic human insulin,and the remaining 24 patients were treated with insulin glargine combined widi insulin aspart.Subcutaneous injection time of insulin glargine was changed from 22;00 to 18;00.Observation was made in fast blood glucose(FBG),postprandial 2 h blood glucose(2hPBG),blood glucose before lunch,the doses of biosynthetic human insulin or insulin aspart and insulin glargine during 3 days before and after variation of injection time,.Results In the patients treated with insulin glargine combined with biosynthetic human insulin,compared with before variation of injection time,FBG and lunch 2hPBG were decreased(P 0.05),moderate hypoglycemia(blood glucose≤2.8 mmol/L) incidents before lunch were significantly reduced(P 0.05).There was no significant difference in conventional hypoglycemia(blood glucose ≤3.9 mmol/L) incidents before lunch(P 0.05).In the patients treated with insulin glargine combined with insulin aspart,compared with before variation of injection time,FBG and lunch 2hPBG were decreased(P 0.05,P 0.01).Conventional hypoglycemia(blood glucose≤3.9 mmol/L) incidents and moderate hypoglycemia(blood glucose≤2.8 mmol/L) incidents before lunch were significantly reduced(P 0.01).There were no significant differences in breakfast and supper 2hPBG,the doses of biosynthetic human insulin or insulin aspart and insulin glargine(P 0.05).Conclusion The result suggests that variation of insulin glargine injection time from 22;00 to 18:00 can stabilize rapidly blood glucose in patients with type 1 diabetes mellitus,even without increasing the doses of insulin.

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【CateGory Index】： R587.1

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  本文关键词：地特胰岛素注射液的临床效果和经济学评价研究综述，由笔耕文化传播整理发布。