红细胞与血小板检测参数在糖尿病血管并发症中的检测价值

发布时间：2017-12-28 01:10

本文关键词：红细胞与血小板检测参数在糖尿病血管并发症中的检测价值　出处：《检验医学与临床》2017年07期 　论文类型：期刊论文

【摘要】：目的探讨红细胞与血小板检测参数在糖尿病血管并发症中的检测价值,分析糖尿病血管并发症的发病因素。方法采用回顾性研究方法,选择北京王府中西医结合医院2013年9月至2015年12月收治的2型糖尿病住院患者188例,包括糖尿病无血管病变120例(对照组)和糖尿病血管病变68例(观察组),所有患者都进行红细胞2项参数与血小板4项参数的检测与相关性分析。结果观察组的空腹血糖(FBG)、餐后2h血糖(PBG)与糖化血红蛋白(HbA1C)值都高于对照组,但差异无统计学意义(P0.05)。观察组的血小板计数(PLT)、平均血小板体积(MPV)、血小板压积(PCT)与血小板分布宽度(PDW)参数分别为(95.42±14.50)×10~9/L、(19.27±2.13)fL、(0.29±0.05)fL和(26.98±2.14)%,而对照组分别为(123.45±25.30)×10~9/L、(14.02±1.46)fL、(0.34±0.11)fL和(18.45±1.68)%;观察组的红细胞分布宽度(RDW)、刚性指数(IR)分别为(0.93±0.04)%和(13.34±2.94)%,对照组分别为(0.76±0.03)%和(11.98±3.13)%,差异有统计学意义(P0.05)。在观察组中,Spearman直线相关分析显示,RDW、IR与MPV、PDW呈显著正相关性,差异有统计学意义(P0.05);而与PLT、PCT有显著负相关性,差异有统计学意义(P0.05);多元逐步Logistic回归显示,RDW、PLT、PCT为导致糖尿病并发症主要的危险因素,差异有统计学意义(P0.05)。结论动态监测血小板4项参数与红细胞2项参数的变化,可以帮助判断糖尿病患者是否存在血管并发症,对预防血管并发症有很好的价值。
[Abstract]:Objective to investigate the detection value of erythrocyte and platelet detection parameters in diabetic vascular complications, and to analyze the pathogenesis of diabetic vascular complications. Methods a retrospective selection combined with type 2 Diabetes Hospital from September 2013 to December 2015 were 188 cases of hospitalized patients in Beijing palace of traditional Chinese and Western medicine, including diabetes vascular lesions in 120 cases (control group) and diabetic vascular lesions in 68 cases (observation group), detection and correlation analysis of all patients were 4 and 2 parameters of red blood cells the parameters and platelet. Results the values of fasting blood glucose (FBG), postprandial 2H blood glucose (PBG) and glycated hemoglobin (HbA1C) were higher in the observation group than in the control group, but the difference was not statistically significant (P0.05). The observation group the platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT) and platelet distribution width (PDW) parameters were (95.42 + 14.50) * 10~9/L (19.27 + 2.13), fL (0.29 + 0.05) fL and (26.98 + 2.14)%, while the control group respectively (123.45 + 25.30) * 10~9/L (14.02 + 1.46), fL (0.34 + 0.11) fL and (18.45 + 1.68)%; red cell distribution width of the observation group (RDW), index of rigidity (IR) respectively (0.93 + 0.04)% and (13.34 + 2.94)%, control group were (0.76 + 0.03)% and (11.98 + 3.13)%, the difference was statistically significant (P0.05). In the observation group, Spearman linear correlation analysis showed that the significant positive correlation between RDW, MPV, IR and PDW, the difference was statistically significant (P0.05); and a significant negative correlation with PLT and PCT, the difference was statistically significant (P0.05); multiple stepwise regression analysis showed that Logistic, RDW, PLT, PCT as main risk the complications of diabetes, the difference was statistically significant (P0.05). Conclusion dynamic monitoring of 4 parameters of platelet and 2 parameters of red blood cell can help to determine whether there is vascular complication in diabetic patients, and has good value in preventing vascular complications.
【作者单位】：北京王府中西医结合医院检验科;河北省衡水市哈励逊国际和平医院外科;北京和睦家医院检验科;河北医科大学第二医院外科;
【基金】：河北省中医药管理局科研计划项目(2013157)
【分类号】：R587.2;R446.1
【正文快照】： 由于各种因素的影响,当前我国2型糖尿病发病率呈显著上升趋势,已成为心血管病、肿瘤后第3大流行性非传染性疾病[1-2]。糖尿病血管并发症是当前糖尿病患者死亡的主要原因之一,其具体的发病机制还不太明确,涉及到蛋白非酶糖化、多元醇旁路代谢增强、血小板功能异常、遗传易感性

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