鼻咽癌患者调强放疗与常规放疗的临床对比观察

发布时间：2017-12-28 09:13

本文关键词：鼻咽癌患者调强放疗与常规放疗的临床对比观察　出处：《中华全科医学》2017年01期 　论文类型：期刊论文

【摘要】：目的观察调强放疗与常规放疗治疗鼻咽癌的急性放射反应和临床疗效。方法筛选2012年6月—2014年11月72例在浙江省人民医院诊治的鼻咽癌患者,按照治疗方法将患者分为对照组和观察组,每组各36例,对照组接受常规放疗,观察组接受调强放疗,化疗方案均采用PF方案(顺铂30 mg/m~2,d_1~d_3;5Fu 500 mg/m~2,d_1~d_5),同步化疗和辅助化疗,放疗均为每天1次,5次/周,观察2组患者的急性放射反应和生存情况。结果观察组患者口干、吞咽疼痛、听力下降及皮肤损伤的发生率分别为63.9%、52.8%、38.9%、50.0%,对照组为94.4%、69.4%、52.8%、72.2%,观察组均明显低于对照组,差异具有统计学意义(χ~2=10.189、4.800、4.503、4.800,P0.05);黏膜损伤方面,观察组发生率为75.0%,对照组为86.1%,观察组少于对照组,但差异无统计学意义(χ~2=3.192,P0.05);截至2016年1月,观察组无局部复发患者,1例远处转移,无死亡病例;对照组有1例局部复发患者,2例远处转移,无死亡病例。结论调强放疗可有效地降低鼻咽癌患者放疗后的急性放射反应,有助于提高临床疗效及患者生存质量。
[Abstract]:Objective To observe the acute radiation reaction and clinical efficacy of intensity modulated radiation therapy and conventional radiotherapy in the treatment of nasopharyngeal carcinoma. June 2012 - November 2014 screening method in 72 cases of nasopharyngeal carcinoma patients in Zhejiang Province People's Hospital for treatment, according to the treatment methods were divided into control group and observation group, 36 cases in each group, the control group received conventional therapy, the observation group received intensity-modulated radiotherapy, chemotherapy with PF scheme (cisplatin 30 mg/m~2, d_1~d_3; 5Fu 500 mg/m~2, d_1~d_5), concurrent chemotherapy and adjuvant chemotherapy, radiotherapy was 1 times a day, 5 times a week, to observe the acute radiation reaction and survival of the 2 groups of patients. Results the observation group patients with xerostomia, odynophagia, hearing loss and the incidence of skin lesions were 63.9%, 52.8%, 38.9%, 50%, 94.4% in the control group, 69.4%, 52.8%, 72.2%, the observation group were significantly lower than the control group, the difference was statistically significant (~2=10.189, 4.800, 4.503, 4.800, P0.05); mucosa the injury incidence rate was 75%, the observation group, the control group was 86.1%, the observation group than the control group, but the difference was not statistically significant (~2=3.192, P0.05); as of January 2016, the observation group of patients with no local recurrence, distant metastasis in 1 cases, there were no deaths; the control group had 1 cases of patients with local recurrence, 2 cases of distant transfer, no deaths. Conclusion the intensity modulated radiation therapy can effectively reduce the acute radiation response of the patients with nasopharyngeal carcinoma after radiotherapy, and help to improve the clinical efficacy and the quality of life of the patients.
【作者单位】：浙江省人民医院放疗科;
【分类号】：R739.63;R730.55
【正文快照】： 鼻咽癌是我国高发恶性肿瘤之一,男性发病率约为女性的2~3倍,40~50岁为高发年龄段[1-2]。鼻咽癌早期可表现为鼻塞、流鼻血、耳鸣等,其症状轻微,常被患者忽视,临床也易出现误诊误治。鼻咽癌多为低分化鳞癌,恶性程度较高,对放疗及化疗敏感,同步放化疗是目前治疗鼻咽癌的主要手段

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