食欲素受体拮抗剂治疗失眠

发布时间：2017-12-28 11:31

本文关键词：食欲素受体拮抗剂治疗失眠　出处：《沈阳药科大学学报》2017年10期 　论文类型：期刊论文

更多相关文章： 失眠症 食欲素 食欲素受体 拮抗剂

【摘要】：目的为治疗失眠症新方法即食欲素受体拮抗剂的深入研究及临床运用提供参考。方法通过web of knowledge、scifinder和pubmed等外文数据库查阅相关文献44篇并对其进行分析与总结。结果现有的治疗方法包括认知行为治疗法(cognitive-behavioral therapy,CBT-I)和药物治疗两大类。由于CBT-I法需花费大量的时间和精力而药物干预法存在许多不良反应,所以在临床中运用都受限。近年来研究发现食欲体系可调节睡眠-醒觉体系,食欲素拮抗剂是一类新型的治疗失眠症的药物且副作用小,现已有大批量的食欲素受体拮抗剂用于失眠的研究。结论食欲素受体拮抗剂是治疗失眠的一类新方法。
[Abstract]:Objective to provide a reference for the further study and clinical application of a new method for the treatment of insomnia, that is, orexin receptor antagonist. Methods through the web of knowledge, SciFinder and PubMed and other foreign language database access to the relevant literature 44 articles and to analyze and summarize it. Results the existing methods of treatment included two major categories: cognitive behavior therapy (cognitive-behavioral therapy, CBT-I) and drug therapy. Because the CBT-I method takes a lot of time and energy, the drug intervention method has many adverse reactions, so it is limited in clinical application. In recent years, it has been found that the appetite system can regulate the sleep wake system. Orexin antagonist is a new kind of medicine for treating insomnia and its side effects are small. Now a large number of orexin receptor antagonists have been used for insomnia research. Conclusion the orexin receptor antagonist is a new method for the treatment of insomnia.
【作者单位】：中南大学药学院;
【分类号】：R740
【正文快照】： 失眠症指难以进入或维持睡眠的生理障碍,患病率随年龄的增长而增加,且与抑郁症密切相关[1]。通过浏览美国“全国睡眠基金会”(nationalsleep foundation,NSF)网站发现,在美国约有48%的人口患有失眠症,其中22%的人严重失眠。更有研究显示,长期失眠将会增加自杀的几率[2-3]。所

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