广西少数民族地区健康人群血管内皮功能的影响因素及超声诊断价值

发布时间：2018-01-01 00:22

本文关键词：广西少数民族地区健康人群血管内皮功能的影响因素及超声诊断价值　出处：《广西医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探讨广西少数民族地区20-80岁健康人群血管内皮功能的影响因素,以及应用高分辨率超声探头检测血管内皮功能的诊断价值。方法:(1)选取长期居住在广西柳州市融安县及融水县20-80岁的健康人群共749人作为研究对象,已排除经临床诊断患有冠心病、脑卒中、外周动脉疾病、肾脏疾病患者;已排除患有糖尿病和高血压的人群;已排除月经期、孕期及哺乳期妇女。(2)收集内容涉及问卷、一般体格检查包括身高体重并计算体重指数,以及应用血管内皮功能检测仪检测右上肢肱动脉血流介导的舒张功能(Flow-mediated dilation,FMD)、反应性充血前后的肱动脉血管内径、血流速度及反应性充血血后血管内径及血流速度出现变化的时间。结果:(1)单因素分析显示:FMD在不同民族、年龄组、性别和吸烟情况差异有统计学意义,而在不同体重指数及喝酒情况差异无统计学意义。(2)Logistic回归分析显示:民族、年龄、性别是FMD的独立影响因素。苗族的FMD较其他民族较高,老年组的FMD明显低于青年组及中年组,女性的FMD高于男性。(3)相关分析表明FMD与肱动脉基础内径、充血反应后最大内径、安静时血流速及充血反应后最大血流速明显负相关,与扩张达峰时间及充血反应后最大血流速出现时间明显正相关;而与充血后血流速反应时间无明显相关性。结论:(1)血管内皮功能存在民族差异性,其中苗族的FMD较高,汉族的FMD较其他少数民族低,因此应重视民族差异对血管内皮功能的影响。(2)同时,年龄及性别差异与血管内皮功能有关。(3)超声检测指标可有效评估血管内皮功能及其变化。
[Abstract]:Objective: To investigate the factors affecting the vascular endothelial function in healthy population aged 20-80 in Guangxi minority area, the diagnostic value and application of high resolution ultrasound probe detection of vascular endothelial function. Methods: (1) choosing long-term healthy people living in the county and Rongshui County of Guangxi at the age of 20-80 in Liuzhou a total of 749 people as the research object, has been ruled out by the clinical diagnosis of coronary heart disease, stroke, peripheral arterial disease, patients with kidney disease were excluded; diabetes and hypertension crowd; have excluded the menstrual period, pregnancy and breast-feeding women. (2) to collect related content and questionnaire, physical examination including height and weight and body mass index, diastolic function and vascular endothelial function detection of right upper limb brachial artery flow mediated (Flow-mediated, dilation, FMD), brachial artery diameter after reactive hyperemia, blood flow velocity and blood reactive hyperemia After the vessel diameter and blood flow velocity changes in time. Results: (1) single factor analysis showed that FMD in different ethnic groups, age groups, there were significant gender and smoking status differences in different body mass index and drinking was no significant difference (2). Logistic regression analysis showed that: age, nationality, sex is the independent factors of FMD. The higher than other ethnic Miao FMD, elderly group FMD was significantly lower than that of the young group and middle-aged group, female FMD than men (3). Correlation analysis showed that FMD and brachial arteries, after the reaction hyperemia diameter, blood velocity and maximum blood flow after quiet congestive reaction speed is obviously negative correlation, positive correlation with the maximum blood flow velocity time dilation and congestion by time after reaction; no significant correlation with blood flow response time after patients. Conclusion: (1) vascular endothelial function of ethnic differences, including seedling The FMD of the ethnic group is higher. The FMD of Han nationality is lower than that of other ethnic groups. Therefore, we should pay attention to the influence of ethnic differences on vascular endothelial function. (2) at the same time, age and gender differences are related to vascular endothelial function. (3) ultrasonography can effectively evaluate endothelial function and its changes.

【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R445.1;R54;R743

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