罗伐他汀对血液透析患者微炎症状态及血脂的影响

发布时间：2018-01-01 16:09

本文关键词：罗伐他汀对血液透析患者微炎症状态及血脂的影响　出处：《实用医学杂志》2017年16期 　论文类型：期刊论文

【摘要】：目的探讨罗伐他汀对血液透析患者微炎症状态及血脂的影响。方法选取2014年4月至2016年4月间入院行血液透析的100例患者,随机分为对照组与治疗组,对照组接受常规血液透析,治疗组在对照组基础上口服罗伐他汀,40 mg,1次/d,比较两组一般资料、微炎症指标、血脂及临床症状。结果对照组与治疗组的年龄、性别、透析龄、体质量、原发病、超滤量、MQSGA评分、血尿素氮(BUN)、血肌酐(Scr)、总胆固醇(TC)、三酰甘油(TG)等指标进行对比,差异无统计学意义;治疗前两组血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、TC、低密度脂蛋白(LDL)、TG、血尿酸(BUA)差异均无显著性;在治疗后3个月,治疗组CRP、IL-6、TNF-α、TG、LDL、TC及BUA均显著低于对照组(P0.05);血液透析治疗中,对照组与治疗组出现乏力为4例vs.0例(8%vs.0%,P=0.04),疲劳症状为7例vs.1例(14%vs.2%,P=0.02),肌肉痉挛为8例vs.2例(16%vs.4%,P=0.04),低血压为5例vs.0例(4%vs.2%,P=0.02),治疗组显著低于对照组。结论罗伐他汀可明显改善血液透析患者微炎症状态,降低血脂,改善透析相关临床症状。
[Abstract]:Objective to investigate the effect of rovastatin on microinflammation and blood lipid in hemodialysis patients. Methods 100 patients who were admitted to hemodialysis from April 2014 to April 2016 were selected. The control group was randomly divided into control group and treatment group. The control group received routine hemodialysis. The treatment group took rovastatin 40 mg / d on the basis of control group. Results the age, sex, dialysis age, body weight, primary disease, ultrafiltration volume and MQSGA score, blood urea nitrogen bun, creatinine creatinine were measured in the control group and the treatment group. There was no significant difference in total cholesterol (TC) and triglyceride (TG). Before the treatment, serum C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor- 伪 (TNF- 伪), low density lipoprotein (LDLT) and triglyceride (TG) were detected in the two groups. There was no significant difference in serum uric acid BUAs. At 3 months after treatment, the TC and BUA of the treatment group were significantly lower than that of the control group (P 0.05). In hemodialysis treatment, 4 cases of vs.0 showed fatigue in the control group and 4 cases in the treatment group, and the fatigue symptom was 14% in 7 cases of vs.1. There were 8 cases of vs.2 with muscle spasm, 16vs.4 with P0.04 and 5 cases with vs.0 with hypotension. Conclusion Lovastatin can significantly improve the microinflammatory state, reduce blood lipid and improve the clinical symptoms of hemodialysis patients.
【作者单位】：华中科技大学同济医学院附属武汉中心医院肾内科;长春中医药大学附属医院风湿科;华中科技大学同济医学院附属武汉中心医院老年科;
【基金】：国家自然青年基金课题(编号:81400734) 湖北省科技厅基金课题(编号:2015CFB241) 武汉市卫计委基金课题(编号:WZ13D08)
【分类号】：R692.5
【正文快照】： 与腹膜透析不同,血液透析能快速有效地清除血液中的毒素与水分,同时专业人员的操作也降低了风险与并发症,患者也能及时反馈病情变化[1],随着居民收入的提高,肾功能衰竭患者中接受血液透析的比例不断升高[2]。尽管如此,血液透析患者中仍存在着低血压、恶心呕吐、头痛、胸背痛

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