2012-2015年某院临床分离2408株非发酵菌耐药性分析

发布时间：2018-01-02 06:19

本文关键词：2012-2015年某院临床分离2408株非发酵菌耐药性分析　出处：《现代预防医学》2017年15期 　论文类型：期刊论文

【摘要】：目的了解临床分离非发酵菌的临床分布及其对常用抗菌药物的耐药状况,为临床合理使用抗菌药物提供依据。方法对2012年1月-2015年12月临床分离的非发酵菌菌种构成、标本来源、科室分布及药敏结果进行回顾性分析。结果 2012-2015年共分离出非发酵菌2 408株,其检出率前四位依次为鲍曼不动杆菌(42.61%)、铜绿假单胞菌(36.34%)、其他不动杆菌属(6.73%)、嗜麦芽窄食单胞菌(6.06%);所有非发酵菌分离株以痰标本为主(占58.63%),其次为引流液(占21.22%);感染科室分布以烧伤科、呼吸内科为主,分别占18.23%、15.86%;药敏显示非发酵菌对抗菌药物耐药较为严重,其中鲍曼不动杆菌对亚胺培南和美罗培南2种抗菌药物耐药率大于66.5%;对头孢类药物敏感性差,对米诺环素耐药率最低,为22.2%;铜绿假单胞菌对大多数抗菌药物耐药率较低;嗜麦芽窄食单胞菌对头孢菌素敏感性差。结论本院临床分离的非发酵菌对常用抗菌药物的耐药情况较为严重,应加强对本地区非发酵菌耐药性的监测,合理使用抗菌药物以遏制耐药菌株的传播流行。
[Abstract]:Objective to investigate the clinical distribution of non-fermentative bacteria and their resistance to common antimicrobial agents. Methods the composition and source of non-fermentative bacteria isolated from January 2012 to December 2015 were studied. Results A total of 2 408 strains of non-fermentative bacteria were isolated from 2012 to 2015. The first four positive rates were Acinetobacter baumannii 42.61). Pseudomonas aeruginosa 36.34, other Acinetobacter spp 6.73 and Maltophilia 6.06; All non-fermentative bacteria isolates were mainly sputum specimens (58.63%), followed by drainage fluid (21.22%). The infection departments were mainly divided into burn department and respiratory department, accounting for 18.23% and 15.86% respectively. The antimicrobial resistance of non-fermentative bacteria was more serious than that of Acinetobacter baumannii to imipenem and meropenem. The antimicrobial resistance rate of Acinetobacter baumannii to imipenem and meropenem was more than 66.5. The sensitivity to cephalosporins was poor, and the resistance rate to minocycline was the lowest (22.2i). The resistance rate of Pseudomonas aeruginosa to most antimicrobial agents was low. Conclusion the drug resistance of non-fermentative bacteria isolated in our hospital to common antimicrobial agents is more serious, and the surveillance of drug resistance of non-fermentative bacteria in this area should be strengthened. Rational use of antimicrobial agents to curb the spread of resistant strains.
【作者单位】：甘肃中医药大学医学技术学院;甘肃省人民医院检验科;
【基金】：甘肃省卫生行业科研基金资助项目(GSWST2012-04)
【分类号】：R446.5
【正文快照】： 非发酵革兰阴性杆菌是指一类不能通过发酵糖类为细菌的生长繁殖提供能量的革兰阴性细菌,主要包括不动杆菌属、假单胞菌属、嗜麦芽窄食单胞菌属、伯克霍尔德菌属等。由于其广泛存在于自然环境中,属于条件致病菌,是医院感染的重要病原菌之一[1],有流行病学数据研究显示,约有四分

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