家兔肝纤维化模型体素内相位不相干运动成像研究

发布时间：2018-01-02 08:13

本文关键词：家兔肝纤维化模型体素内相位不相干运动成像研究　出处：《中国医学影像学杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的评价体素内相位不相干运动(IVIM)成像在家兔肝纤维化分期中的诊断价值。材料与方法构建家兔肝纤维化不同时期的模型,进行多b值(分别为0、50、100、200、300、800、1000、1200 s/mm~2)IVIM成像,并最终按肝纤维化病理分期相应将实验家兔分为S1~S4 4组,测量不同时期纤维化肝脏IVIM双指数模型扩散系数D值,灌注相关扩散系数D*值及灌注分数f值,比较对照组(仅注射生理盐水)与S1组、S2组与S3组的参数。结果对照组家兔D值高于S1组家兔,差异有统计学意义(P0.05),而D*值及f值差异无统计学意义(P0.05)。随着肝纤维化级别的增加,D、D*及f值也逐渐减低。其中,S2组与S3组的D*值差异有统计学意义(P0.05),而D值和f值差异无统计学意义(P0.05)。结论 D值有助于鉴别正常肝脏及肝纤维化S1期,D*值有助于鉴别S2及S3期的肝纤维化,而f值则不能发现早期肝纤维化,也不能帮助进行肝纤维化分期。IVIM成像提供了一种无创的肝纤维化早期及准确分期的方法,可为临床诊治提供帮助。
[Abstract]:Objective to evaluate the diagnostic value of voxel phase incoherent motion imaging (IVIMI) in the staging of hepatic fibrosis in rabbits. 50, 100, 200, 300, 300, 800, 1000, 1200 s / mm, 2, IVIM imaging. Finally, the experimental rabbits were divided into four groups according to the pathological stages of liver fibrosis. The diffusion coefficient D of IVIM double index model of liver fibrosis in different period was measured. The parameters of the control group, S1 group, S 2 group and S 3 group were compared. Results the D value of the control group was higher than that of the S1 group. The difference was statistically significant (P 0.05), but there was no significant difference in D * and f values. With the increase of liver fibrosis grade, the D * and f values decreased gradually. The difference of D * between S2 group and S3 group was statistically significant (P 0.05). But there was no significant difference between D value and f value (P 0.05). Conclusion D value is helpful for differentiating normal liver from liver fibrosis in S1 stage and differentiating liver fibrosis in S2 and S3 stages. The value of f can not detect early hepatic fibrosis, nor can it help to carry out hepatic fibrosis staging. IVIM provides a noninvasive method for early and accurate staging of liver fibrosis, which can be helpful for clinical diagnosis and treatment.
【作者单位】：成都大学附属医院放射科;川北医学院附属医院放射科;通用电气医疗集团;
【分类号】：R-332;R445.2;R575.2
【正文快照】： 肝纤维化早期的确诊及分期对防止其进展到肝硬化甚至肝癌的意义重大[1-2]。磁共振扩散加权成像(DWI)及基于单指数的表观扩散系数(ADC)值对肝纤维化诊断价值已有较多研究;然而ADC值出现明显变化时往往已是肝纤维化晚期。早期肝纤维化与正常肝脏ADC值之间并无显著差异,故早期发

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