遵义汉族人群载脂蛋白A5基因多态性与高胆固醇血症的关系

发布时间：2018-01-02 12:41

本文关键词：遵义汉族人群载脂蛋白A5基因多态性与高胆固醇血症的关系　出处：《中国动脉硬化杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的探讨载脂蛋白A5(Apo A5)基因c.553G/T位点多态性与遵义汉族人群高胆固醇血症(HTC)的相关性。方法采用聚合酶链反应限制性片长多态性(PCR-RFLP)技术检测并分析101例HTC患者和118例正常对照者Apo A5基因c.553G/T位点多态性。结果两组中Apo A5基因c.553G/T位点基因型频率差异有统计学意义(P0.05),Apo A5 c.553T基因在HTC患者组中的分布频率明显高于正常对照组(P0.05),对HTC有独立影响(OR=4.685,95%CI:1.269~17.296,P=0.020);各血脂指标比较更进一步验证血脂指标比值比单相血脂检测更具临床意义。结论 Apo A5 c.553G/T位点多态性与遵义汉族人群HTC发病存在相关性;Apo A5 c.553T等位基因可能是HTC的独立危险因素。
[Abstract]:Objective to investigate the relationship between the polymorphism of apolipoprotein A5 apo A5) gene c. 553 G / T and hypercholesterolemia in Zunyi Han population. Methods Polymerase chain reaction restriction fragment length polymorphism PCR-RFLP was used. The polymorphism of Apo A5 gene c. 553 G / T locus in 101 patients with HTC and 118 normal controls was detected and analyzed. Results Apo was detected in both groups. The genotype frequencies of A5 gene c. 553G / T locus were significantly different (P < 0.05). P0.05). The distribution frequency of Apo A5 c. 553T gene in HTC group was significantly higher than that in normal control group (P0. 05), and had an independent effect on HTC. 95 CI: 1.269, 17.296, Pu, 0.020; The ratio of blood lipid index is more significant than that of monophasic blood lipid detection. Conclusion Apo A5 is more important than monophasic blood lipid detection. The polymorphism of c. 553 G / T locus was associated with the incidence of HTC in Zunyi Han population. Apo A 5 c. 553 T allele may be an independent risk factor for HTC.
【作者单位】：遵义医学院附属医院检验科;遵义医学院;遵义医学院医学遗传学教研室;
【基金】：贵州省科技厅项目(黔科合J字LKZ[2012]39号) 遵义医学院大学生创新创业训练计划项目(院发[2014]5828)
【分类号】：R440;R589.2
【正文快照】： 高脂血症是由遗传和环境因素共同作用而产生的一种全身性疾病。临床上根据血液生化检测结果将高脂血症分为高甘油三酯血症(hypertriglyceridemia,HTG)、高胆固醇血症(hyper total cholesterolemia,HTC)、混合型高脂血症(mixed hyperlipidemia)和低高密度脂蛋白血症(low high d

【相似文献】