三维面积应变早期检测Duchenne型肌营养不良儿童亚临床左室收缩功能损伤

发布时间：2018-01-05 15:39

本文关键词：三维面积应变早期检测Duchenne型肌营养不良儿童亚临床左室收缩功能损伤　出处：《中国超声医学杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的探讨三维斑点追踪超声心动图成像(3D-STE)整体面积应变(GAS)早期检测Duchenne型肌营养不良(DMD)患儿亚临床左室收缩功能损伤的可行性及临床意义。方法选取51例DMD患儿及31例正常对照儿童。应用二维及三维超声心动图检查获得左心室二维及三维左心室射血分数(LVEF)以及左室GAS。比较两组左心室收缩功能指标的差异。结果 DMD组与正常对照组的二维超声心动图指标差异无统计学意义(均P0.05)。与正常对照组相比,DMD组三维容积指标及左室射血分数无明显变化(均P0.05),而GAS显著减低(-26.5±5.8vs-30.7±4.05,P0.01),差异有统计学意义。结论三维面积应变可定量评估DMD患儿左心室收缩功能,早期检测出DMD患儿的左室收缩功能损伤,为临床对DMD患儿心脏功能损伤的早期干预和判断预后提供有价值的参考。
[Abstract]:Objective to investigate the early detection of Duchenne type muscular dystrophy by 3D-STE (3D-STE) global area strain (GASS) in three dimensional speckle tracing echocardiography (3D-STE). The feasibility and clinical significance of subclinical left ventricular systolic function injury in children. Methods 51 children with DMD and 31 normal children were selected. Two-dimensional and three-dimensional echocardiography were used to obtain left ventricular two-dimensional and three-dimensional echocardiography. Left ventricular ejection fraction (LVEF). Results there was no significant difference in left ventricular systolic function between DMD group and normal control group (P 0.05). Compared with the normal control group. In DMD group, there was no significant change in 3D volume index and left ventricular ejection fraction (P0.05, P 0.01), but GAS decreased significantly (-26.5 卤5.8 vs-30.7 卤4.05). Conclusion Three-dimensional area strain can be used to quantitatively evaluate left ventricular systolic function in children with DMD and early detection of left ventricular systolic function injury in children with DMD. To provide a valuable reference for early intervention and prognosis of heart function injury in children with DMD.
【作者单位】：深圳市儿童医院超声科;深圳市儿童医院神经肌肉病研究室;
【基金】：深圳市卫生计生系统科研项目(No.201402051) 深圳市科技研发资金基础研究项目(No.JCYJ20140416141331487)
【分类号】：R445.1;R746.2
【正文快照】： 杜氏型肌营养不良(duchenne　muscular　dystro-phy,DMD)为临床常见儿童致死性肌萎缩疾病,存活男婴发病率约为1/3　500[1]。本病是X连锁隐性遗传性肌变性疾病,由于染色体上抗肌萎缩蛋白基因缺陷所致。心脏病变日益成为患者死亡的首要原因。超声心动图是临床最常用评估DMD心脏

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