慢性内脏痛的病理机制研究和临床治疗新进展

发布时间：2018-01-05 15:17

本文关键词：慢性内脏痛的病理机制研究和临床治疗新进展　出处：《中国疼痛医学杂志》2017年01期 　论文类型：期刊论文

【摘要】：慢性内脏痛(Chronic Visceral Pain,CVP)是指来自内脏器官的疼痛,它有别于躯体痛。功能性胃肠疾病如肠易激综合症(Irritable Bowel Syndrome,IBS)病人常常伴有慢性内脏痛。由于CVP的病理机制尚未完全阐明和新疗法的发展缓慢,因此,目前针对内脏痛的治疗手段非常有限且效果不佳。建立更符合临床疾病特征的实验动物模型是研究CVP发病机制和设计个体化治疗举措的关键所在。已有的研究表明环境因素和应激等不良刺激与CVP的发生发展密不可分。在这篇综述里,我们将以慢性内脏痛中功能性胃肠疾病为例,首先介绍用于模拟CVP的啮齿类动物模型,并从应激、炎症、肠道菌群紊乱和免疫功能改变等多方面讨论慢性内脏痛的病因和病理机制;最后,我们还对功能性胃肠疾病如IBS和慢性胰腺炎性内脏痛的新的潜在治疗方法和举措进行了归纳和分析。
[Abstract]:Chronic visceral pain (Visceral) refers to pain from the visceral organs. It is different from body pain. Functional gastrointestinal diseases such as irritable Bowel Syndrome. The pathological mechanism of CVP is not fully elucidated and the development of new therapy is slow. At present, the treatment of visceral pain is very limited and the effect is not good. It is the key to study the pathogenesis of CVP and design individualized treatment measures to establish experimental animal model which accords with the characteristics of clinical diseases. The results show that adverse stimuli such as environmental factors and stress are closely related to the occurrence and development of CVP. In this review. We will take the functional gastrointestinal disease in chronic visceral pain as an example, first introduce the rodent model used to simulate CVP, and start with stress and inflammation. The etiology and pathological mechanism of chronic visceral pain were discussed from many aspects, such as intestinal flora disorder and immune function change. Finally, we also summarize and analyze new potential treatments for functional gastrointestinal diseases such as IBS and chronic pancreatitis viscera pain.
【作者单位】：苏州大学神经科学研究所苏州大学附属第二医院;
【基金】：国家自然科学基金委资助(81230024,81471137和31400947)
【分类号】：R402
【正文快照】： 张弘弘孙艳徐广银Δ(苏州大学神经科学研究所苏州大学附属第二医院,苏州215123)慢性内脏痛(CVP)是临床上报道的慢性疼痛中最常见的疼痛形式之一,其发生率高达20%。内脏痛是指来自机体内部器官的疼痛,常与多种疾病相关,如急慢性胰腺炎,胰腺肿瘤,胆囊结石,急性阑尾炎,憩室炎,功

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