人血清穿透素-3对脓毒症的诊断意义及预测价值研究

发布时间：2018-01-07 00:18

本文关键词：人血清穿透素-3对脓毒症的诊断意义及预测价值研究　出处：《临床和实验医学杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的研究人血清穿透素-3(PTX-3)在脓毒症诊断及判断脓毒症严重程度中的作用,为脓毒症的早期准确诊断、提高抗菌药物治疗效果、降低患者死亡率以及改善预后提供新的诊断依据。方法选取2014年9月1日至2016年8月31日首都医科大学附属北京友谊医院重症医学科收治的符合标准的32例非感染性全身炎症反应综合征(SIRS)患者,40例脓毒症患者,其中脓毒性休克患者16例;另选取同期体检的健康志愿者24例作为对照组。所有研究对象入选24 h即记录基本信息,包括年龄、性别、体温、呼吸频率、心率、收缩压、舒张压和急性生理学与慢性健康状况评分系统II(APACHE II)评分等,同时用酶联免疫吸附法检测血清PTX-3水平,比较各组血清PTX-3水平。结果脓毒症组患者PTX-3水平为18.64±10.39 ng/ml,非感染性SIRS组患者PTX-3水平为9.93±6.19 ng/ml,对照组健康志愿者PTX-3水平为1.19±0.38 ng/ml,脓毒症患者与非感染性SIRS患者PTX-3水平均明显高于对照组,差异有统计学意义(P0.05),且脓毒症患者PTX-3水平明显高于非感染性SIRS患者,差异有统计学意义(P0.05)。脓毒症组患者PTX-3含量为12.65±8.78 ng/m L,脓毒性休克组患者PTX-3含量为27.63±4.39 ng/ml,脓毒性休克组患者的PTX3水平明显高于脓毒症组患者PTX-3水平,差异有统计学意义(P0.05)。结论脓毒症时患者血清PTX-3浓度明显升高,PTX-3水平与脓毒症严重程度相关,可作为脓毒症病情预测的参考指标。
[Abstract]:Objective to study the serum pentraxin -3 (PTX-3) in the diagnosis of sepsis and judging the severity of sepsis in the role for the accurate diagnosis of early sepsis, improve antimicrobial treatment effect, reduce the mortality of patients provides a new diagnostic method and improve the prognosis. Methods from September 1, 2014 to August 31, 2016 in ICU of Beijing Friendship Hospital affiliated to Capital Medical University from 32 patients with non infectious systemic inflammatory response syndrome (SIRS) patients, 40 cases of sepsis patients, including 16 cases of patients with septic shock; the other selected 24 cases of healthy volunteers as control group. All subjects were 24 h record basic information, including age, gender, body temperature, respiratory rate, heart rate, systolic blood pressure, diastolic blood pressure and acute physiology and chronic health evaluation II (APACHE II) score, at the same time by enzyme-linked immunosorbent assay Detection of serum PTX-3 levels, serum PTX-3 levels were compared. Results the levels of PTX-3 in patients with sepsis was 18.64 + 10.39 ng/ml, non infected patients in the SIRS group PTX-3 level was 9.93 + 6.19 ng/ml, the control group of healthy volunteers, PTX-3 level of 1.19 + 0.38 ng/ml, patients with sepsis and non infection level in patients with PTX-3 SIRS were significantly higher than the control group, the difference was statistically significant (P0.05), and the level of PTX-3 in patients with sepsis was significantly higher than that in patients with non infectious SIRS, the difference was statistically significant (P0.05) in patients with sepsis. The content of PTX-3 is 12.65 + 8.78 ng/m L, septic shock group, the content of PTX-3 is 27.63 + 4.39 ng/ml septic shock group, the serum PTX3 levels were significantly higher than that in sepsis group with PTX-3 levels, the difference was statistically significant (P0.05). Conclusion sepsis in patients with serum PTX-3 concentration increased significantly, PTX-3 level and the severity of sepsis, as can be A reference index for the prediction of sepsis.

【作者单位】：首都医科大学附属北京友谊医院临床检验中心;
【基金】：首都临床特色应用研究项目(2141107006614005)
【分类号】：R459.7
【正文快照】： 脓毒症是具有明确感染过程的全身炎症反应综合征(systemic inflammatory response syndrome,SIRS),可诱发脓毒性休克和多器官功能障碍综合征(multiple organdysfunction syndrome,MODS),甚至导致死亡。脓毒症早期诊断对于采取有效抗菌治疗、提高疗效和改善预后至关重要。目前,

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