乳腺Paget病临床及超声影像学特征

发布时间：2018-01-10 08:24

本文关键词：乳腺Paget病临床及超声影像学特征　出处：《中国医学科学院学报》2017年03期 　论文类型：期刊论文

【摘要】：目的总结分析乳腺Paget病的临床表现及超声图像特征。方法以术后组织病理学诊断为标准,对34例乳腺Paget病的临床资料、超声表现进行分析,总结乳腺Paget病的临床表现和超声声像图特征。结果 34例患者中,单一Paget病7例,合并浸润性导管癌16例,合并导管原位癌7例,同时合并浸润性导管癌和导管内癌3例,合并其他病理类型癌1例;有Paget病典型临床表现的24例,无Paget病典型临床表现的10例。24例有Paget病典型临床表现的患者中,超声提示乳头或乳晕区回声异常11例,乳腺肿物14例,微钙化14例;10例无Paget病典型临床表现的患者中,超声提示乳头或乳晕区回声异常3例,乳腺肿物9例,微钙化6例。14例超声提示乳头或乳晕区回声异常的患者中,彩色多普勒超声均提示乳头局部血流丰富。结论乳腺Paget病主要表现为乳头或乳晕区皮肤的改变,高频超声可敏感识别乳头及乳晕区回声异常。对于超声发现的乳腺病灶,应对其乳头及乳晕区进行仔细扫查,避免Paget病漏诊。
[Abstract]:Objective to summarize the clinical manifestation and ultrasound image feature analysis of Paget's disease of the breast. Methods the postoperative histopathological diagnosis as the standard, the clinical data of 34 cases with Paget disease of the breast, analyze the ultrasonic manifestation of Paget's disease of the breast, summarize the clinical manifestations and ultrasonographic features. Results of the 34 patients, 7 cases of single Paget disease, with 16 cases of infiltrating ductal carcinoma, 7 cases with ductal carcinoma in situ, combined with invasive ductal carcinoma and ductal carcinoma in 3 cases, combined with other pathological types of carcinoma in 1 cases; 24 cases had typical clinical manifestations of Paget disease, 10 cases of.24 patients with typical clinical manifestations of Paget disease with typical clinical manifestations of Paget disease the patients, ultrasound echo nipple or areola of breast abnormalities in 11 cases, 14 cases of breast tumor, micro calcification in 14 cases; 10 cases of patients with Paget disease without typical clinical manifestations in the nipple or areola of breast ultrasound echo abnormalities in 3 cases, 9 cases of breast tumor, micro calcification in 6 cases.14 Cases of ultrasound echo nipple or areola of breast abnormalities in patients with color Doppler ultrasound showed papillary local rich blood. Conclusion Paget disease of the breast is mainly the nipple or areola skin changes, the high-frequency ultrasonic echo sensitive identification of the nipple and areola area. The ultrasound found abnormal breast lesions, the nipple and areola of breast careful scanning, avoid Paget disease misdiagnosis.

【作者单位】：中国医学科学院北京协和医学院北京协和医院超声医学科;
【基金】：国家自然科学基金(81371557)~~
【分类号】：R445.1;R739.5
【正文快照】： Acta Acad Med Sin,2017,39(3):396-400乳腺Paget病(mammary Paget’s disease,MPD)是一种罕见病,约占所有女性乳腺癌的1.0%~4.3%,最早在1874年由英国病理学家Jame Paget首次描述并报道[1]。MPD以发现表皮内赘生性细胞为特征,常合并导管原位癌(ductal carcinoma in situ,DCIS)

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