静息态下早期帕金森病患者杏仁核功能连接的MRI研究

发布时间：2018-01-15 06:07

本文关键词：静息态下早期帕金森病患者杏仁核功能连接的MRI研究　出处：《临床放射学杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的采用静息态功能磁共振成像探讨早期帕金森病(PD)患者杏仁核功能连接(rsFC)的特点及意义。方法对29例早期PD患者(PD组)及30名健康对照者(HC组)行颅脑静息态功能磁共振扫描,选双侧杏仁核为感兴趣区,PD组与HC组间脑功能连接差异用双样本t检验,并采用国际通用的统计参数图。结果与HC组相比,早期PD组中双侧壳核、前扣带回;右中央前回、前额叶、岛叶;左胼胝体下回、苍白球与双侧杏仁核rsFC减低;右额内侧回、颞下回;左楔叶、舌回、枕下回;双侧顶上小叶、枕中回、楔前叶与双侧杏仁核rsFC增强。右额内侧回、右岛叶与帕金森病综合评分(UPDRS)呈正相关,左苍白球及右壳核与UPDRS评分呈负相关。结论早期PD患者静息态下杏仁核已存在异常功能连接,可能与PD多系统受累的复杂病理机制密切相关。
[Abstract]:Objective to investigate the characteristics and significance of amygdaloid nucleus functional junction (rsFC) in patients with early Parkinson's disease (PD) by resting functional magnetic resonance imaging (fMRI). Methods 29 patients with early PD were enrolled in this study. Brain rest functional magnetic resonance imaging was performed in HC group and 30 healthy controls. The diencephalon functional junction difference between PD group and HC group was compared with that of HC group. The bilateral putamen nucleus in early PD group was compared with that in HC group. Anterior cingulate gyrus; Right precentral gyrus, prefrontal lobe, island lobe; Left corpus callosum inferior gyrus, globus pallidus and bilateral amygdala rsFC decreased; Right medial frontal gyrus, inferior temporal gyrus; Left cuneate lobe, lingual gyrus, suboccipital gyrus; Bilateral superior lobule, middle occipital gyrus, anterior cuneate lobe and bilateral amygdaloid nucleus rsFC were enhanced, and right medial frontal gyrus, right insular lobe and Parkinson's disease comprehensive score were positively correlated. Conclusion there is an abnormal functional connection in the amygdala in the resting state of early PD patients, which may be closely related to the complex pathological mechanism of multiple system involvement of PD.
【作者单位】：昆明医科大学第一附属医院影像科;
【分类号】：R445.2;R742.5
【正文快照】： 帕金森病(Parkision disease,PD)是一种中枢神经系统退行性疾病。PD的病理基础是黑质-纹状体多巴胺能神经元缺失,使纹状体多巴胺含量下降,导致锥体外系功能障碍,临床上表现为静止性震颤、运动迟缓、肌强直和姿势平衡障碍为主的运动障碍症状。但研究证实PD病变并不局限在黑质,

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