哺乳期与非哺乳期患者乳腺脓肿病原菌分布及耐药性分析

发布时间：2018-01-16 17:30

本文关键词：哺乳期与非哺乳期患者乳腺脓肿病原菌分布及耐药性分析　出处：《中华医院感染学杂志》2017年16期 　论文类型：期刊论文

【摘要】：目的对比哺乳期与非哺乳期乳腺脓肿患者的病原菌分布及耐药性。方法选取医院2013年6月-2016年3月142例哺乳期乳腺脓肿患者为哺乳期组,76例非哺乳期乳腺脓肿患者为非哺乳期组,行细菌培养、分离、鉴定及药敏试验,对比两组病原菌分布与耐药情况。结果哺乳期患者检出病原菌株167株,其中革兰阳性球菌160株占95.81%,革兰阴性杆菌7株占4.19%,非哺乳期患者检出病原菌株86株,其中革兰阳性球菌62株占72.09%,革兰阴性杆菌22株占25.58%,真菌2株占2.33%;哺乳期患者革兰阳性球菌检出率显著高于非哺乳期(P0.01),革兰阴性杆菌及真菌检出率显著低于非哺乳期患者(P0.05);哺乳期患者金黄色葡萄球菌检出率79.04%显著高于非哺乳期患者34.88%,差异有统计学意义(P0.01);哺乳期患者金黄色葡萄球菌对苯唑西林、左氧氟沙星、红霉素、克林霉素、利福平的耐药性显著低于非哺乳期患者,差异有统计学意义(P0.05)。结论哺乳期与非哺乳期乳腺脓肿患者致病菌检出率以及对某些药物的敏感性存在明显差异,应针对不同患者选择敏感抗菌药物,以提高治疗效果,避免抗菌药物滥用现象的发生。
[Abstract]:Objective to compare the distribution and drug resistance of pathogenic bacteria between breast abscess and breast abscess during lactation and non-lactation. Methods 142 breast abscess patients in hospital from June 2013 to March 2016 were selected as lactation group. 76 cases of breast abscess in non-lactation period were treated with bacterial culture, isolation, identification and drug sensitivity test. The distribution and drug resistance of pathogenic bacteria were compared between the two groups. Results 167 strains of pathogens were detected in lactation period. Among them, 160 strains of Gram-positive cocci accounted for 95.81%, 7 strains of Gram-negative bacilli accounted for 4.19, 86 strains of pathogenic bacteria were detected in non-lactation patients, among which 62 strains of Gram-positive cocci accounted for 72.09%. Gram-negative bacilli accounted for 25.58 strains and fungi 2 strains for 2.33%. The detection rate of Gram-positive cocci in lactation patients was significantly higher than that in non-lactation patients, and the detection rate of Gram-negative bacilli and fungi was significantly lower than that in non-lactation patients. The detection rate of Staphylococcus aureus in breast-feeding patients was significantly higher than that in non-lactation patients (P 0.01). The resistance of Staphylococcus aureus to oxacillin, levofloxacin, erythromycin, clindamycin and rifampicin in lactation patients was significantly lower than that in non-lactation patients. Conclusion the detection rate of pathogenic bacteria and the sensitivity to some drugs in breast abscess patients during lactation and non-lactation are significantly different. Sensitive antimicrobial agents should be selected for different patients in order to improve the therapeutic effect and avoid the occurrence of antimicrobial abuse.
【作者单位】：安阳市人民医院妇产科;安阳市北关区医保中心;
【分类号】：R446.5;R655.8
【正文快照】： 表现为乳房局部疼痛、肿胀、硬块,局部皮肤发红、皮温增高等,也可伴有全身性发热。乳腺炎按照乳腺功能状态可分为哺乳期乳腺炎与非哺乳期乳腺炎,临床多见为哺乳期急性乳腺炎发展成为乳腺脓肿。急性乳腺炎是哺乳期女性较为常见的疾病,属于乳腺的一种急性化脓性感染,在产妇中发

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