CD71、CD80及IgA在紫癜性肾炎中表达特征的研究

发布时间：2018-01-17 01:08

本文关键词：CD71、CD80及IgA在紫癜性肾炎中表达特征的研究　出处：《现代预防医学》2017年12期 　论文类型：期刊论文

【摘要】：目的探讨CD71、CD80在紫癜性肾炎(HSPN)患者肾脏损害中的作用以及CD71与IgA的关系。方法采用SP法检测免疫标记IgA、CD71、CD80在肾组织的表达情况。结果与正常对照组相比,CD71表达与BUN和ALB组间的差异有统计学意义。CD80表达与24 h尿蛋白定量、尿蛋白定性、BUN、ALB组间的差异有统计学意义。病理分型与CD71的表达呈负相关。结论 HSPN患者CD71均仅在远曲小管表达,CD80表达于近曲小管、远曲小管及肾间质,IgA均表达于肾小球系膜和/或毛细血管袢。IgA的表达与CD71的表达无相关性。
[Abstract]:Objective to investigate the role of CD71 and CD80 in renal damage and the relationship between CD71 and IgA in patients with Henoch-Schonlein purpura nephritis (HSPN). The expression of CD71 and CD80 in renal tissue was compared with that in normal control group. The expression of CD71 was significantly different from that of BUN and ALB. The expression of CD80 was correlated with the quantity of 24 h urine protein and the qualitative analysis of urinary protein bun. The expression of CD71 was negatively correlated with the expression of CD71 in patients with ALB. Conclusion the expression of CD80 in the distal tubules of patients with HSPN is only expressed in the proximal tubules. There was no correlation between the expression of IgA in glomerular Mesangial and / or capillary loops and the expression of CD71.
【作者单位】：四川大学华西第二医院临床检验科出生缺陷与相关妇儿疾病教育部重点实验室;四川大学华西医院病理科;
【基金】：四川省科技厅科技支撑项目(2014KJT058-2014SZ0001)
【分类号】：R446.6;R692.34
【正文快照】： 过敏性紫癜(Henoch-Schonlein Purpura,HSP)是一种系统性弥漫性小血管炎,紫癜性肾炎(Henoch-Schonlein Purpura Nephritis,HSPN)是以Ig A免疫复合物沉积在肾组织而导致的肾脏损害。国内外报道HSPN在HSP中发生率分别为30%~50%和40%~50%,占儿童泌尿系统疾病8%,仅次于急性肾炎[1-

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